Lithium-Mediated Zincation of Pyrazine, Pyridazine, Pyrimidine, and Quinoxaline

Deprotonation of pyrazine, pyridazine, pyrimidine, and quinoxaline using an in situ mixture of ZnCl2·TMEDA (0.5 equiv) and LiTMP (1.5 equiv) was studied. Pyrazine and pyrimidine were deprotonated in THF at room temperature, a result evidenced by trapping with I2. The competitive formation of dimer o...

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Veröffentlicht in:	Journal of organic chemistry 2007-08, Vol.72 (17), p.6602-6605
Hauptverfasser:	Seggio, Anne, Chevallier, Floris, Vaultier, Michel, Mongin, Florence
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Lithium - chemistry Magnetic Resonance Spectroscopy Mass Spectrometry Organic chemistry Preparations and properties Pyrazines - chemistry Pyridazines - chemistry Pyrimidines - chemistry Quinoxalines - chemistry Zinc - chemistry
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