Fidelity and spatio‐temporal control in MAP kinase (ERKs) signalling

The mitogen activated protein (MAP) kinase module: (Raf →MEK→ERKs) is central to the control of cell growth, cell differentiation and cell survival. The fidelity of signalling and the spatio‐temporal activation are key determinants in generating precise biological responses. The fidelity is ensured...

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Veröffentlicht in:	European Journal of Biochemistry 2003-08, Vol.270 (16), p.3291-3299
Hauptverfasser:	Pouysségur, Jacques, Lenormand, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biochemistry, Molecular Biology Cancer cell signalling growth control Life Sciences MAP kinases MAPK‐phosphatases Mice Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - physiology nucleus Protein Isoforms scaffolding proteins Signal Transduction Signal Transduction - genetics Signal Transduction - physiology
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