Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats
Bilateral intradentate injections of 3.0μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant associative learning deficit in an olfactory discriminati...
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| Veröffentlicht in: | Neurobiology of learning and memory 2008-07, Vol.90 (1), p.185-191 |
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| container_title | Neurobiology of learning and memory |
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| creator | Marchetti, E. Jacquet, M. Jeltsch, H. Migliorati, M. Nivet, E. Cassel, J.C. Roman, F.S. |
| description | Bilateral intradentate injections of 3.0μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant associative learning deficit in an olfactory discrimination task, while being unimpaired in the procedural component of this task. Injection of a partial selective 5-HT4 agonist (SL65.0155; 0.01mg/kg, i.p., vs. saline) before the third of six training sessions enabled complete recovery of associative learning performance in the lesioned rats. Activation of 5-HT4 receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as Alzheimer’s disease. |
| doi_str_mv | 10.1016/j.nlm.2008.03.010 |
| format | Article |
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All rats with such lesions showed a significant associative learning deficit in an olfactory discrimination task, while being unimpaired in the procedural component of this task. Injection of a partial selective 5-HT4 agonist (SL65.0155; 0.01mg/kg, i.p., vs. saline) before the third of six training sessions enabled complete recovery of associative learning performance in the lesioned rats. Activation of 5-HT4 receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as Alzheimer’s disease.</description><identifier>ISSN: 1074-7427</identifier><identifier>EISSN: 1095-9564</identifier><identifier>DOI: 10.1016/j.nlm.2008.03.010</identifier><identifier>PMID: 18485752</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>5-HT4 receptors ; Alzheimer's disease ; Animals ; Association Learning ; Association Learning - drug effects ; Association Learning - physiology ; Behavior, Animal ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Colchicine ; Colchicine - toxicity ; Denervation ; Dentate Gyrus ; Dentate Gyrus - pathology ; Dentate Gyrus - physiology ; Dioxanes ; Dioxanes - pharmacology ; Discrimination Learning ; Discrimination Learning - drug effects ; Discrimination Learning - physiology ; Fundamental and applied biological sciences. Psychology ; Learning ; Life Sciences ; Male ; Memory ; Memory Disorders ; Memory Disorders - drug therapy ; Memory Disorders - physiopathology ; Neurology ; Neurons and Cognition ; Olfactory associative discrimination task ; Oxadiazoles ; Oxadiazoles - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Pyramidal Cells ; Pyramidal Cells - pathology ; Pyramidal Cells - physiology ; Rats ; Rats, Long-Evans ; Receptors, Serotonin, 5-HT4 ; Receptors, Serotonin, 5-HT4 - physiology ; Reversal Learning ; Reversal Learning - drug effects ; Reversal Learning - physiology ; Rodents ; Serotonin 5-HT4 Receptor Agonists ; SL65.0155 ; Smell ; Smell - physiology</subject><ispartof>Neurobiology of learning and memory, 2008-07, Vol.90 (1), p.185-191</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-f2d1883eb9b93bb040c0ffc601ad804d07c445635091f0f356afe4df2fa6b43</citedby><cites>FETCH-LOGICAL-c470t-f2d1883eb9b93bb040c0ffc601ad804d07c445635091f0f356afe4df2fa6b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nlm.2008.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20467710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18485752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00320770$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchetti, E.</creatorcontrib><creatorcontrib>Jacquet, M.</creatorcontrib><creatorcontrib>Jeltsch, H.</creatorcontrib><creatorcontrib>Migliorati, M.</creatorcontrib><creatorcontrib>Nivet, E.</creatorcontrib><creatorcontrib>Cassel, J.C.</creatorcontrib><creatorcontrib>Roman, F.S.</creatorcontrib><title>Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats</title><title>Neurobiology of learning and memory</title><addtitle>Neurobiol Learn Mem</addtitle><description>Bilateral intradentate injections of 3.0μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. 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Activation of 5-HT4 receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as Alzheimer’s disease.</description><subject>5-HT4 receptors</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Association Learning</subject><subject>Association Learning - drug effects</subject><subject>Association Learning - physiology</subject><subject>Behavior, Animal</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Colchicine</subject><subject>Colchicine - toxicity</subject><subject>Denervation</subject><subject>Dentate Gyrus</subject><subject>Dentate Gyrus - pathology</subject><subject>Dentate Gyrus - physiology</subject><subject>Dioxanes</subject><subject>Dioxanes - pharmacology</subject><subject>Discrimination Learning</subject><subject>Discrimination Learning - drug effects</subject><subject>Discrimination Learning - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Learning</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - physiopathology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Olfactory associative discrimination task</subject><subject>Oxadiazoles</subject><subject>Oxadiazoles - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Pyramidal Cells</subject><subject>Pyramidal Cells - pathology</subject><subject>Pyramidal Cells - physiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Receptors, Serotonin, 5-HT4</subject><subject>Receptors, Serotonin, 5-HT4 - physiology</subject><subject>Reversal Learning</subject><subject>Reversal Learning - drug effects</subject><subject>Reversal Learning - physiology</subject><subject>Rodents</subject><subject>Serotonin 5-HT4 Receptor Agonists</subject><subject>SL65.0155</subject><subject>Smell</subject><subject>Smell - physiology</subject><issn>1074-7427</issn><issn>1095-9564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxSNERUvhA3BBFogDh4Rx4j-JeqpWwFZaqQd6txxnvHjlxIudXakXPjsOuyonevL46TdvRvOK4h2FigIVX3bV5MeqBmgraCqg8KK4otDxsuOCvVxqyUrJanlZvE5pB0Ap79pXxSVtWcslr6-K36sw7j3OSCKacMT4SIIlwVtt5pA_OqVgnJ7dEYlHHSc3bUmfdZOlLIdp4Xm5fmCLA-5zVyLazhjJgNOss_M26ungkRj0ngx61FskbiJRz-lNcWG1T_j2_F4XP759fVity83997vV7aY0TMJc2nqgbdtg3_Vd0_fAwIC1RgDVQwtsAGkY46Lh0FELtuFCW2SDra0WPWuui88n15_aq310o46PKmin1rcbtWgATQ1SwpFm9sOJ3cfw64BpVrtwiFNeTtWNoEzWkmfo4_8gKvJlKRewjKUnysSQUkT7NJuCWgJUO5UDVEuAChqVA8w978_Oh37E4V_HObEMfDoDOhntbb6tcemJq4EJKf8a3Zw4zGc9OowqGYeTwcHlnGY1BPfMGn8AwTa33g</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Marchetti, E.</creator><creator>Jacquet, M.</creator><creator>Jeltsch, H.</creator><creator>Migliorati, M.</creator><creator>Nivet, E.</creator><creator>Cassel, J.C.</creator><creator>Roman, F.S.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope></search><sort><creationdate>20080701</creationdate><title>Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats</title><author>Marchetti, E. ; Jacquet, M. ; Jeltsch, H. ; Migliorati, M. ; Nivet, E. ; Cassel, J.C. ; Roman, F.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-f2d1883eb9b93bb040c0ffc601ad804d07c445635091f0f356afe4df2fa6b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>5-HT4 receptors</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Association Learning</topic><topic>Association Learning - drug effects</topic><topic>Association Learning - physiology</topic><topic>Behavior, Animal</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Colchicine</topic><topic>Colchicine - toxicity</topic><topic>Denervation</topic><topic>Dentate Gyrus</topic><topic>Dentate Gyrus - pathology</topic><topic>Dentate Gyrus - physiology</topic><topic>Dioxanes</topic><topic>Dioxanes - pharmacology</topic><topic>Discrimination Learning</topic><topic>Discrimination Learning - drug effects</topic><topic>Discrimination Learning - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Learning</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders</topic><topic>Memory Disorders - drug therapy</topic><topic>Memory Disorders - physiopathology</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Olfactory associative discrimination task</topic><topic>Oxadiazoles</topic><topic>Oxadiazoles - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Pyramidal Cells</topic><topic>Pyramidal Cells - pathology</topic><topic>Pyramidal Cells - physiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Receptors, Serotonin, 5-HT4</topic><topic>Receptors, Serotonin, 5-HT4 - physiology</topic><topic>Reversal Learning</topic><topic>Reversal Learning - drug effects</topic><topic>Reversal Learning - physiology</topic><topic>Rodents</topic><topic>Serotonin 5-HT4 Receptor Agonists</topic><topic>SL65.0155</topic><topic>Smell</topic><topic>Smell - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marchetti, E.</creatorcontrib><creatorcontrib>Jacquet, M.</creatorcontrib><creatorcontrib>Jeltsch, H.</creatorcontrib><creatorcontrib>Migliorati, M.</creatorcontrib><creatorcontrib>Nivet, E.</creatorcontrib><creatorcontrib>Cassel, J.C.</creatorcontrib><creatorcontrib>Roman, F.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurobiology of learning and memory</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchetti, E.</au><au>Jacquet, M.</au><au>Jeltsch, H.</au><au>Migliorati, M.</au><au>Nivet, E.</au><au>Cassel, J.C.</au><au>Roman, F.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats</atitle><jtitle>Neurobiology of learning and memory</jtitle><addtitle>Neurobiol Learn Mem</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>90</volume><issue>1</issue><spage>185</spage><epage>191</epage><pages>185-191</pages><issn>1074-7427</issn><eissn>1095-9564</eissn><abstract>Bilateral intradentate injections of 3.0μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant associative learning deficit in an olfactory discrimination task, while being unimpaired in the procedural component of this task. Injection of a partial selective 5-HT4 agonist (SL65.0155; 0.01mg/kg, i.p., vs. saline) before the third of six training sessions enabled complete recovery of associative learning performance in the lesioned rats. Activation of 5-HT4 receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as Alzheimer’s disease.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18485752</pmid><doi>10.1016/j.nlm.2008.03.010</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurobiology of learning and memory, 2008-07, Vol.90 (1), p.185-191 |
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| subjects | 5-HT4 receptors Alzheimer's disease Animals Association Learning Association Learning - drug effects Association Learning - physiology Behavior, Animal Behavior, Animal - drug effects Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Colchicine Colchicine - toxicity Denervation Dentate Gyrus Dentate Gyrus - pathology Dentate Gyrus - physiology Dioxanes Dioxanes - pharmacology Discrimination Learning Discrimination Learning - drug effects Discrimination Learning - physiology Fundamental and applied biological sciences. Psychology Learning Life Sciences Male Memory Memory Disorders Memory Disorders - drug therapy Memory Disorders - physiopathology Neurology Neurons and Cognition Olfactory associative discrimination task Oxadiazoles Oxadiazoles - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Cells Pyramidal Cells - pathology Pyramidal Cells - physiology Rats Rats, Long-Evans Receptors, Serotonin, 5-HT4 Receptors, Serotonin, 5-HT4 - physiology Reversal Learning Reversal Learning - drug effects Reversal Learning - physiology Rodents Serotonin 5-HT4 Receptor Agonists SL65.0155 Smell Smell - physiology |
| title | Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats |
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