MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7

Proteolytic degradation of the extracellular matrix (ECM) is one intrinsic property of metastatic tumor cells to breach tissue barriers and to disseminate into different tissues. This process is initiated by the formation of invadopodia, which are actin-driven, finger-like membrane protrusions. Yet,...

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Veröffentlicht in:	Current biology 2008-06, Vol.18 (12), p.926-931
Hauptverfasser:	Steffen, Anika, Le Dez, Gaëlle, Poincloux, Renaud, Recchi, Chiara, Nassoy, Pierre, Rottner, Klemens, Galli, Thierry, Chavrier, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Surface Extensions Cell Surface Extensions - enzymology CELLBIO Cellular Biology Extracellular Matrix Extracellular Matrix - metabolism Gene Expression Regulation, Neoplastic Humans Life Sciences Matrix Metalloproteinase 14 Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Neurons and Cognition R-SNARE Proteins R-SNARE Proteins - metabolism Subcellular Processes
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