Relationships between Early Inflammatory Response to Bleomycin and Sensitivity to Lung Fibrosis: A Role for Dipeptidyl-Peptidase I and Tissue Inhibitor of Metalloproteinase-3?

Different sensitivities to profibrotic compounds such as bleomycin are observed among mouse strains. To identify genetic factors contributing to the outcome of lung injury. Physiological comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2007-12, Vol.176 (11), p.1098-1107
Hauptverfasser:	Pottier, Nicolas, Chupin, Cecile, Defamie, Virginie, Cardinaud, Bruno, Sutherland, Rachel, Rios, Geraldine, Gauthier, Francis, Wolters, Paul J, Berthiaume, Yves, Barbry, Pascal, Mari, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins ADAM Proteins - metabolism ADAM17 Protein Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Apoptosis Biological and medical sciences Bleomycin Bleomycin - administration & dosage Blood coagulation. Blood cells Blood. Blood coagulation. Reticuloendothelial system Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Fluid - chemistry Cathepsin C - deficiency Cathepsin C - metabolism Dipeptidyl Peptidase I Eosinophilia Eosinophilia - chemically induced Eosinophilia - etiology Fundamental and applied biological sciences. Psychology Gene Expression Profiling General aspects, investigation methods, hemostasis, fibrinolysis Genetic Predisposition to Disease Human health and pathology Instillation, Drug Intensive care medicine Interleukin-5 Interleukin-5 - metabolism Life Sciences Lung Lung - metabolism Male Matrix Metalloproteinases Matrix Metalloproteinases - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred BALB C - genetics Mice, Inbred BALB C - metabolism Mice, Inbred C57BL Mice, Inbred C57BL - genetics Mice, Inbred C57BL - metabolism Mice, Knockout Molecular and cellular biology Neutrophils Neutrophils - enzymology Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Pneumonia Pneumonia - chemically induced Pneumonia - metabolism Pneumonia - physiopathology Pulmonary Fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Serine Endopeptidases Serine Endopeptidases - metabolism Species Specificity Tissue Inhibitor of Metalloproteinase-3 Tissue Inhibitor of Metalloproteinase-3 - metabolism Trachea Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - metabolism
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