Development of a hemicornea from human primary cell cultures for pharmacotoxicology testing

We report the reconstruction and characterization of a hemicornea (epithelialized stroma), using primary human cells, for use in research and as an alternative to the use of animals in pharmacotoxicology testing. To create a stromal equivalent, keratocytes from human corneas were cultured in collage...

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Veröffentlicht in:	Cell biology and toxicology 2007-07, Vol.23 (4), p.279-292
Hauptverfasser:	Builles, N, Bechetoille, N, Justin, V, André, V, Barbaro, V, Di Iorio, E, Auxenfans, C, Hulmes, D J S, Damour, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Biochemistry, Molecular Biology Biomarkers - metabolism Cell Adhesion Molecules - metabolism Cell Culture Techniques - methods Cells, Cultured Collagen Collagen Type IV - metabolism Collagen Type IV - ultrastructure Cornea - cytology Cornea - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Extracellular Matrix - metabolism Hemidesmosomes - metabolism Humans Kalinin Life Sciences Membrane Proteins - metabolism Physiology Proteins Stem cells Stem Cells - cytology Stem Cells - metabolism Stromal Cells - cytology Stromal Cells - metabolism
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