Sequence and pH Effects of LNA-Containing Triple Helix-Forming Oligonucleotides: Physical Chemistry, Biochemistry, and Modeling Studies

Triple helix-forming oligonucleotides (TFOs) have been demonstrated to be capable of interfering with gene expression and modifying genomic DNA in a sequence-specific manner. Partial incorporation of 2‘-O,4‘-C-methylene linked locked nucleic acid (LNA) residues in TFOs has been shown to enhance sign...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2004-04, Vol.43 (14), p.4160-4169
Hauptverfasser:	Sun, Bei-Wen, Babu, B. Ravindra, Sørensen, Mads D, Zakrzewska, Krystyna, Wengel, Jesper, Sun, Jian-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biochemistry, Molecular Biology Deoxyribonucleases, Type II Site-Specific - chemistry DNA - chemistry Hot Temperature Hydrocarbons Hydrogen-Ion Concentration Hydrolysis Life Sciences Methane - analogs & derivatives Methane - chemistry Models, Molecular Nucleic Acid Conformation Nucleic Acid Heteroduplexes - chemistry Oligodeoxyribonucleotides - chemistry Purine Nucleotides - chemistry Pyrimidine Nucleotides - chemistry Restriction Mapping Spectrophotometry, Ultraviolet Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!