Detection of exogenous hydrocortisone in horse urine by gas chromatography–combustion–carbon isotope ratio mass spectrometry
A gas chromatography–combustion–isotope ratio mass spectrometry method for confirmation of hydrocortisone abuse in horseracing and equine sports is proposed. Urinary hydrocortisone was converted to a bismethylenedioxy derivative which presents good gas chromatographic properties and brings an extra...
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| Veröffentlicht in: | Journal of chromatography. B, Biomedical sciences and applications Biomedical sciences and applications, 1997-11, Vol.702 (1), p.85-91 |
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| container_end_page | 91 |
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| container_title | Journal of chromatography. B, Biomedical sciences and applications |
| container_volume | 702 |
| creator | Aguilera, R. Becchi, M. Mateus, L. Popot, M.A. Bonnaire, Y. Casabianca, H. Hatton, C.K. |
| description | A gas chromatography–combustion–isotope ratio mass spectrometry method for confirmation of hydrocortisone abuse in horseracing and equine sports is proposed. Urinary hydrocortisone was converted to a bismethylenedioxy derivative which presents good gas chromatographic properties and brings an extra carbon contribution of only two carbon atoms. Synthetic hydrocortisone has a different
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abundance from that of natural urinary horse hydrocortisone and the difference is significant, therefore exogenous and endogenous hydrocortisone can be distinguished. |
| doi_str_mv | 10.1016/S0378-4347(97)00375-7 |
| format | Article |
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abundance from that of natural urinary horse hydrocortisone and the difference is significant, therefore exogenous and endogenous hydrocortisone can be distinguished.</description><identifier>ISSN: 0378-4347</identifier><identifier>ISSN: 1387-2273</identifier><identifier>DOI: 10.1016/S0378-4347(97)00375-7</identifier><identifier>PMID: 9449559</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - urine ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Carbon Isotopes ; Corticosteroids ; Doping in Sports ; Drug intoxications. Doping ; Gas Chromatography-Mass Spectrometry - methods ; Horses - metabolism ; Horses - urine ; Hydrocortisone ; Hydrocortisone - chemistry ; Hydrocortisone - urine ; Life Sciences ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of chromatography. B, Biomedical sciences and applications, 1997-11, Vol.702 (1), p.85-91</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-695f466f41b10732930e581732cffe35dc2631e0ddbed837f02689a8c4bd6c983</citedby><cites>FETCH-LOGICAL-c489t-695f466f41b10732930e581732cffe35dc2631e0ddbed837f02689a8c4bd6c983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2281477$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9449559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00314107$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Aguilera, R.</creatorcontrib><creatorcontrib>Becchi, M.</creatorcontrib><creatorcontrib>Mateus, L.</creatorcontrib><creatorcontrib>Popot, M.A.</creatorcontrib><creatorcontrib>Bonnaire, Y.</creatorcontrib><creatorcontrib>Casabianca, H.</creatorcontrib><creatorcontrib>Hatton, C.K.</creatorcontrib><title>Detection of exogenous hydrocortisone in horse urine by gas chromatography–combustion–carbon isotope ratio mass spectrometry</title><title>Journal of chromatography. B, Biomedical sciences and applications</title><addtitle>J Chromatogr B Biomed Sci Appl</addtitle><description>A gas chromatography–combustion–isotope ratio mass spectrometry method for confirmation of hydrocortisone abuse in horseracing and equine sports is proposed. Urinary hydrocortisone was converted to a bismethylenedioxy derivative which presents good gas chromatographic properties and brings an extra carbon contribution of only two carbon atoms. Synthetic hydrocortisone has a different
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abundance from that of natural urinary horse hydrocortisone and the difference is significant, therefore exogenous and endogenous hydrocortisone can be distinguished.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - urine</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Carbon Isotopes</subject><subject>Corticosteroids</subject><subject>Doping in Sports</subject><subject>Drug intoxications. Doping</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Horses - metabolism</subject><subject>Horses - urine</subject><subject>Hydrocortisone</subject><subject>Hydrocortisone - chemistry</subject><subject>Hydrocortisone - urine</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Doping</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Horses - metabolism</topic><topic>Horses - urine</topic><topic>Hydrocortisone</topic><topic>Hydrocortisone - chemistry</topic><topic>Hydrocortisone - urine</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Pharmacology. 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abundance from that of natural urinary horse hydrocortisone and the difference is significant, therefore exogenous and endogenous hydrocortisone can be distinguished.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9449559</pmid><doi>10.1016/S0378-4347(97)00375-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4347 |
| ispartof | Journal of chromatography. B, Biomedical sciences and applications, 1997-11, Vol.702 (1), p.85-91 |
| issn | 0378-4347 1387-2273 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - urine Biochemistry, Molecular Biology Biological and medical sciences Carbon Isotopes Corticosteroids Doping in Sports Drug intoxications. Doping Gas Chromatography-Mass Spectrometry - methods Horses - metabolism Horses - urine Hydrocortisone Hydrocortisone - chemistry Hydrocortisone - urine Life Sciences Medical sciences Pharmacology. Drug treatments |
| title | Detection of exogenous hydrocortisone in horse urine by gas chromatography–combustion–carbon isotope ratio mass spectrometry |
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