The Pro-regions of Lysyl Oxidase and Lysyl Oxidase-like 1 Are Required for Deposition onto Elastic Fibers

These studies were undertaken to determine how lysyl oxidase (LOX) and lysyl oxidase like-1 (LOXL) enzymes are targeted to their substrates in the extracellular matrix. Full-length LOX/LOXL and constructs containing just the pro-regions of each enzyme localized to elastic fibers when expressed in cu...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (52), p.42848-42855
Hauptverfasser:	Thomassin, Laetitia, Werneck, Claudio C., Broekelmann, Thomas J., Gleyzal, Claudine, Hornstra, Ian K., Mecham, Robert P., Sommer, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - chemistry Amino Acid Oxidoreductases - metabolism Animals Biochemistry, Molecular Biology Catalytic Domain DNA - metabolism DNA, Complementary - metabolism Extracellular Matrix - metabolism Fluorescent Antibody Technique, Indirect HeLa Cells Humans Life Sciences Ligands Luciferases - metabolism Mice Microscopy, Fluorescence Mutagenesis Protein Binding Protein Structure, Tertiary Protein-Lysine 6-Oxidase - chemistry Recombinant Proteins - chemistry Recombinant Proteins - metabolism Transfection Tropoelastin - chemistry Two-Hybrid System Techniques
Online-Zugang:	Volltext
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