The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and ε, is still poorly understood. To examine their role in TCR function, we have constructed...
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| Veröffentlicht in: | Cell 1992-01, Vol.68 (1), p.83-95 |
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| creator | Wegener, Anne-Marie K. Letourneur, François Hoeveler, Arnd Brocker, Thomas Luton, Frédéric Malissen, Bernard |
| description | Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and ε, is still poorly understood. To examine their role in TCR function, we have constructed TCR/CD3 complexes devoid of functional ζ subunit and showed that they are still able to trigger the production of interleukin-2 in response to antigen or superantigen. These data, together with previous results, indicate that the TCR/CD3 complex is composed of at least two parallel transducing units, made of the γδε and ζ chains, respectively, Furthermore, the analysis of partially truncated ζ chains has led us to individualize a functional domain that may have constituted the building block of most of the transducing subunits associated with antigen receptors and some Fc receptors. |
| doi_str_mv | 10.1016/0092-8674(92)90208-T |
| format | Article |
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However, the function of the remaining invariant subunits, CD3-γ, -δ, and ε, is still poorly understood. To examine their role in TCR function, we have constructed TCR/CD3 complexes devoid of functional ζ subunit and showed that they are still able to trigger the production of interleukin-2 in response to antigen or superantigen. These data, together with previous results, indicate that the TCR/CD3 complex is composed of at least two parallel transducing units, made of the γδε and ζ chains, respectively, Furthermore, the analysis of partially truncated ζ chains has led us to individualize a functional domain that may have constituted the building block of most of the transducing subunits associated with antigen receptors and some Fc receptors.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(92)90208-T</identifier><identifier>PMID: 1531041</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Antigens, Differentiation, T-Lymphocyte - genetics ; Base Sequence ; Biochemistry, Molecular Biology ; CD3 antigen ; CD3 Complex ; CD8 Antigens - genetics ; Cell Line ; Chimera ; Chromosome Deletion ; Flow Cytometry ; Gene Expression ; Interleukin-2 - biosynthesis ; Life Sciences ; lymphocytes T ; Mice ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Plasmids ; Polymerase Chain Reaction - methods ; Receptors, Antigen, T-Cell - genetics ; signal transduction ; T-Lymphocytes - immunology ; Thymoma ; Thymus Neoplasms ; Transfection</subject><ispartof>Cell, 1992-01, Vol.68 (1), p.83-95</ispartof><rights>1992</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-25945149244c01f4463e32e2f34a83638f4b91ceba13db4c3902c85d5fa045803</citedby><cites>FETCH-LOGICAL-c383t-25945149244c01f4463e32e2f34a83638f4b91ceba13db4c3902c85d5fa045803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/009286749290208T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1531041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00314006$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Wegener, Anne-Marie K.</creatorcontrib><creatorcontrib>Letourneur, François</creatorcontrib><creatorcontrib>Hoeveler, Arnd</creatorcontrib><creatorcontrib>Brocker, Thomas</creatorcontrib><creatorcontrib>Luton, Frédéric</creatorcontrib><creatorcontrib>Malissen, Bernard</creatorcontrib><title>The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules</title><title>Cell</title><addtitle>Cell</addtitle><description>Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. 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Letourneur, François ; Hoeveler, Arnd ; Brocker, Thomas ; Luton, Frédéric ; Malissen, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-25945149244c01f4463e32e2f34a83638f4b91ceba13db4c3902c85d5fa045803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens, Differentiation, T-Lymphocyte - genetics</topic><topic>Base Sequence</topic><topic>Biochemistry, Molecular Biology</topic><topic>CD3 antigen</topic><topic>CD3 Complex</topic><topic>CD8 Antigens - genetics</topic><topic>Cell Line</topic><topic>Chimera</topic><topic>Chromosome Deletion</topic><topic>Flow Cytometry</topic><topic>Gene Expression</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Life Sciences</topic><topic>lymphocytes T</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Oligodeoxyribonucleotides</topic><topic>Plasmids</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>signal transduction</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymoma</topic><topic>Thymus Neoplasms</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wegener, Anne-Marie K.</creatorcontrib><creatorcontrib>Letourneur, François</creatorcontrib><creatorcontrib>Hoeveler, Arnd</creatorcontrib><creatorcontrib>Brocker, Thomas</creatorcontrib><creatorcontrib>Luton, Frédéric</creatorcontrib><creatorcontrib>Malissen, Bernard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wegener, Anne-Marie K.</au><au>Letourneur, François</au><au>Hoeveler, Arnd</au><au>Brocker, Thomas</au><au>Luton, Frédéric</au><au>Malissen, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>68</volume><issue>1</issue><spage>83</spage><epage>95</epage><pages>83-95</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and ε, is still poorly understood. To examine their role in TCR function, we have constructed TCR/CD3 complexes devoid of functional ζ subunit and showed that they are still able to trigger the production of interleukin-2 in response to antigen or superantigen. These data, together with previous results, indicate that the TCR/CD3 complex is composed of at least two parallel transducing units, made of the γδε and ζ chains, respectively, Furthermore, the analysis of partially truncated ζ chains has led us to individualize a functional domain that may have constituted the building block of most of the transducing subunits associated with antigen receptors and some Fc receptors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1531041</pmid><doi>10.1016/0092-8674(92)90208-T</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Antigens, Differentiation, T-Lymphocyte - genetics Base Sequence Biochemistry, Molecular Biology CD3 antigen CD3 Complex CD8 Antigens - genetics Cell Line Chimera Chromosome Deletion Flow Cytometry Gene Expression Interleukin-2 - biosynthesis Life Sciences lymphocytes T Mice Molecular Sequence Data Oligodeoxyribonucleotides Plasmids Polymerase Chain Reaction - methods Receptors, Antigen, T-Cell - genetics signal transduction T-Lymphocytes - immunology Thymoma Thymus Neoplasms Transfection |
| title | The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules |
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