Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), represented by nonstructural protein 5B (NS5B), is believed to form a membrane-associated RNA replication complex together with other nonstructural proteins and as yet unidentified host components. However, the determinants for membran...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (47), p.44052-44063
Hauptverfasser:	Schmidt-Mende, Juliane, Bieck, Elke, Hügle, Thomas, Penin, François, Rice, Charles M., Blum, Hubert E., Moradpour, Darius
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biochemistry, Molecular Biology Cell Line Cell Membrane - metabolism Cell Membrane - virology DNA Primers Endoplasmic Reticulum - metabolism Fluorescent Antibody Technique Hepacivirus - enzymology Hepatitis C virus Humans Life Sciences Molecular Sequence Data NS5B protein Protein Biosynthesis RNA-Dependent RNA Polymerase - metabolism Sequence Homology, Amino Acid Tetracycline - pharmacology Transcription, Genetic Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism
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