Frequent compartmentalization of hepatitis C virus variants in circulating B cells and monocytes

Differences in the composition of the hepatitis C virus (HCV) quasispecies between plasma and blood mononuclear cells (BMC) strongly suggest that BMCs support viral replication. We examined the frequency of such compartmentalization, the cell types involved, the constraints exerted on the different...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2004-03, Vol.39 (3), p.817-825
Hauptverfasser:	Ducoulombier, Delphine, Roque‐Afonso, Anne‐Marie, Di Liberto, Gaëtana, Penin, François, Kara, Rachid, Richard, Yolande, Dussaix, Elisabeth, Féray, Cyrille
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Sequence B-Lymphocytes - virology Biochemistry, Molecular Biology Biological and medical sciences Entropy Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation Hepacivirus - genetics Human viral diseases Humans Immunoglobulin G - metabolism Infectious diseases Life Sciences Male Medical sciences Middle Aged Monocytes - virology Phylogeny Plasma RNA, Viral - blood Viral diseases Viral hepatitis Viral Proteins - genetics
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