Molecular structure of a barley α-amylase-inhibitor complex: implications for starch binding and catalysis

α-Amylases are widely occurring, multidomain proteins with a catalytic (β/α) 8-barrel. In barley α-amylase, insight into the catalytic mechanism is gained from the X-ray crystal structure of its molecular complex with acarbose, a pseudotetrasaccharide that acts like a transition-state analogue and w...

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