Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat
The effect of malotilate, a new drug proposed for the treatment of chronic liver diseases, was studied in carbon tetrachloride (CCl 4)-induced chronic liver injury in the rat. Treatment with CCl 4 (0.5 ml/kg twice per week, intraperitoneally for 6 or 9 weeks) led to marked necrosis, steatosis and fi...
Gespeichert in:
| Veröffentlicht in: | Journal of hepatology 1986, Vol.3 (2), p.260-268 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | 2 |
| container_start_page | 260 |
| container_title | Journal of hepatology |
| container_volume | 3 |
| creator | Dumont, J.-M. Maignan, M.-F. Janin, B. Herbage, D. Perrissoud, D. |
| description | The effect of malotilate, a new drug proposed for the treatment of chronic liver diseases, was studied in carbon tetrachloride (CCl
4)-induced chronic liver injury in the rat. Treatment with CCl
4 (0.5 ml/kg twice per week, intraperitoneally for 6 or 9 weeks) led to marked necrosis, steatosis and fibrosis, as shown by both biochemical and histological examinations, and a significant decrease of the bromosulfophtaleine (BSP) clearance test. Malotilate (50 mg/kg p.o., 5 days per week given simultaneously with CCl
4 for 6 weeks), suppressed the increase of plasma aminotransferase activity and decreased significantly the accumulation of lipid and collagen in the liver; histology confirmed this protective effect of malotilate. The BSP clearance test returned to normal values and the rise in hepatic collagen synthesis activity in the malotilate-treated and intoxicated rats was reduced as compared with intoxicated control rats. The same effect was found when malotilate (100 mg/kg, p.o., 5 days per week), was given for 3 weeks to rats already intoxicated during the 6 previous weeks. Malotilate was able to prevent the increase of hepatic alterations that appeared during the last 3 weeks of CCl
4 intoxication. These results show clearly that malotilate can markedly reduce the hepatic disorders induced by a chronic CCl
4 intoxication in the rat. |
| doi_str_mv | 10.1016/S0168-8278(86)80036-8 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00313357v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827886800368</els_id><sourcerecordid>S0168827886800368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-25ed72cfb33ca0f601e39bb3ca13fd8b9ab0fe8b2aba7d74156d3adcdc71e9223</originalsourceid><addsrcrecordid>eNqFkUFLwzAUx4MoOqcfQcjBgztUk6ZN05MMmU4YeFDxGF6SFxbpWkm7wb69mRu7eskjeb__I_mFkBvO7jnj8uE9LSpTeaXulJwoxoTM1AkZcclYxmTBT8noiFyQy77_ZglidXFOzkVVF4LJEfmaeY92oJ2nK2i6ITQwIO1aapexa4OlTdhgpKH9XsdtKm5t0VGzpRaiSdiAQwS7bLoYHKY-HZZIIwxX5MxD0-P1oY7J5_Ps42meLd5eXp-mi8wWuRiyvERX5dYbISwwLxlHURuTNlx4p0wNhnlUJgcDlasKXkonwFlnK451nosxmeznLqHRPzGsIG51B0HPpwu9O0tP5kKU1YYnttyzNnZ9H9EfA5zpnVP951TvhGkl9Z9TrVLuZp_7WZsVumPqIDH1bw996C00PkJrQ3_EVF5IWYqEPe4xTD42AaPubcA2-QwxfYF2XfjnIr8QqpPO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Dumont, J.-M. ; Maignan, M.-F. ; Janin, B. ; Herbage, D. ; Perrissoud, D.</creator><creatorcontrib>Dumont, J.-M. ; Maignan, M.-F. ; Janin, B. ; Herbage, D. ; Perrissoud, D.</creatorcontrib><description>The effect of malotilate, a new drug proposed for the treatment of chronic liver diseases, was studied in carbon tetrachloride (CCl
4)-induced chronic liver injury in the rat. Treatment with CCl
4 (0.5 ml/kg twice per week, intraperitoneally for 6 or 9 weeks) led to marked necrosis, steatosis and fibrosis, as shown by both biochemical and histological examinations, and a significant decrease of the bromosulfophtaleine (BSP) clearance test. Malotilate (50 mg/kg p.o., 5 days per week given simultaneously with CCl
4 for 6 weeks), suppressed the increase of plasma aminotransferase activity and decreased significantly the accumulation of lipid and collagen in the liver; histology confirmed this protective effect of malotilate. The BSP clearance test returned to normal values and the rise in hepatic collagen synthesis activity in the malotilate-treated and intoxicated rats was reduced as compared with intoxicated control rats. The same effect was found when malotilate (100 mg/kg, p.o., 5 days per week), was given for 3 weeks to rats already intoxicated during the 6 previous weeks. Malotilate was able to prevent the increase of hepatic alterations that appeared during the last 3 weeks of CCl
4 intoxication. These results show clearly that malotilate can markedly reduce the hepatic disorders induced by a chronic CCl
4 intoxication in the rat.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(86)80036-8</identifier><identifier>PMID: 3794306</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Animals ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Body Weight - drug effects ; Carbon Tetrachloride ; Chronic Disease ; Collagen - biosynthesis ; Digestive system ; Life Sciences ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis, Experimental - chemically induced ; Liver Cirrhosis, Experimental - drug therapy ; Liver Cirrhosis, Experimental - metabolism ; Liver Cirrhosis, Experimental - pathology ; Male ; Malonates - therapeutic use ; Medical sciences ; Organ Size - drug effects ; Pharmacology. Drug treatments ; Rats</subject><ispartof>Journal of hepatology, 1986, Vol.3 (2), p.260-268</ispartof><rights>1986 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1987 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-25ed72cfb33ca0f601e39bb3ca13fd8b9ab0fe8b2aba7d74156d3adcdc71e9223</citedby><cites>FETCH-LOGICAL-c423t-25ed72cfb33ca0f601e39bb3ca13fd8b9ab0fe8b2aba7d74156d3adcdc71e9223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8278(86)80036-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,4022,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8246653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3794306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00313357$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumont, J.-M.</creatorcontrib><creatorcontrib>Maignan, M.-F.</creatorcontrib><creatorcontrib>Janin, B.</creatorcontrib><creatorcontrib>Herbage, D.</creatorcontrib><creatorcontrib>Perrissoud, D.</creatorcontrib><title>Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The effect of malotilate, a new drug proposed for the treatment of chronic liver diseases, was studied in carbon tetrachloride (CCl
4)-induced chronic liver injury in the rat. Treatment with CCl
4 (0.5 ml/kg twice per week, intraperitoneally for 6 or 9 weeks) led to marked necrosis, steatosis and fibrosis, as shown by both biochemical and histological examinations, and a significant decrease of the bromosulfophtaleine (BSP) clearance test. Malotilate (50 mg/kg p.o., 5 days per week given simultaneously with CCl
4 for 6 weeks), suppressed the increase of plasma aminotransferase activity and decreased significantly the accumulation of lipid and collagen in the liver; histology confirmed this protective effect of malotilate. The BSP clearance test returned to normal values and the rise in hepatic collagen synthesis activity in the malotilate-treated and intoxicated rats was reduced as compared with intoxicated control rats. The same effect was found when malotilate (100 mg/kg, p.o., 5 days per week), was given for 3 weeks to rats already intoxicated during the 6 previous weeks. Malotilate was able to prevent the increase of hepatic alterations that appeared during the last 3 weeks of CCl
4 intoxication. These results show clearly that malotilate can markedly reduce the hepatic disorders induced by a chronic CCl
4 intoxication in the rat.</description><subject>Animals</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Carbon Tetrachloride</subject><subject>Chronic Disease</subject><subject>Collagen - biosynthesis</subject><subject>Digestive system</subject><subject>Life Sciences</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis, Experimental - chemically induced</subject><subject>Liver Cirrhosis, Experimental - drug therapy</subject><subject>Liver Cirrhosis, Experimental - metabolism</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Male</subject><subject>Malonates - therapeutic use</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFLwzAUx4MoOqcfQcjBgztUk6ZN05MMmU4YeFDxGF6SFxbpWkm7wb69mRu7eskjeb__I_mFkBvO7jnj8uE9LSpTeaXulJwoxoTM1AkZcclYxmTBT8noiFyQy77_ZglidXFOzkVVF4LJEfmaeY92oJ2nK2i6ITQwIO1aapexa4OlTdhgpKH9XsdtKm5t0VGzpRaiSdiAQwS7bLoYHKY-HZZIIwxX5MxD0-P1oY7J5_Ps42meLd5eXp-mi8wWuRiyvERX5dYbISwwLxlHURuTNlx4p0wNhnlUJgcDlasKXkonwFlnK451nosxmeznLqHRPzGsIG51B0HPpwu9O0tP5kKU1YYnttyzNnZ9H9EfA5zpnVP951TvhGkl9Z9TrVLuZp_7WZsVumPqIDH1bw996C00PkJrQ3_EVF5IWYqEPe4xTD42AaPubcA2-QwxfYF2XfjnIr8QqpPO</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Dumont, J.-M.</creator><creator>Maignan, M.-F.</creator><creator>Janin, B.</creator><creator>Herbage, D.</creator><creator>Perrissoud, D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope></search><sort><creationdate>1986</creationdate><title>Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat</title><author>Dumont, J.-M. ; Maignan, M.-F. ; Janin, B. ; Herbage, D. ; Perrissoud, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-25ed72cfb33ca0f601e39bb3ca13fd8b9ab0fe8b2aba7d74156d3adcdc71e9223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Carbon Tetrachloride</topic><topic>Chronic Disease</topic><topic>Collagen - biosynthesis</topic><topic>Digestive system</topic><topic>Life Sciences</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis, Experimental - chemically induced</topic><topic>Liver Cirrhosis, Experimental - drug therapy</topic><topic>Liver Cirrhosis, Experimental - metabolism</topic><topic>Liver Cirrhosis, Experimental - pathology</topic><topic>Male</topic><topic>Malonates - therapeutic use</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumont, J.-M.</creatorcontrib><creatorcontrib>Maignan, M.-F.</creatorcontrib><creatorcontrib>Janin, B.</creatorcontrib><creatorcontrib>Herbage, D.</creatorcontrib><creatorcontrib>Perrissoud, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumont, J.-M.</au><au>Maignan, M.-F.</au><au>Janin, B.</au><au>Herbage, D.</au><au>Perrissoud, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1986</date><risdate>1986</risdate><volume>3</volume><issue>2</issue><spage>260</spage><epage>268</epage><pages>260-268</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>The effect of malotilate, a new drug proposed for the treatment of chronic liver diseases, was studied in carbon tetrachloride (CCl
4)-induced chronic liver injury in the rat. Treatment with CCl
4 (0.5 ml/kg twice per week, intraperitoneally for 6 or 9 weeks) led to marked necrosis, steatosis and fibrosis, as shown by both biochemical and histological examinations, and a significant decrease of the bromosulfophtaleine (BSP) clearance test. Malotilate (50 mg/kg p.o., 5 days per week given simultaneously with CCl
4 for 6 weeks), suppressed the increase of plasma aminotransferase activity and decreased significantly the accumulation of lipid and collagen in the liver; histology confirmed this protective effect of malotilate. The BSP clearance test returned to normal values and the rise in hepatic collagen synthesis activity in the malotilate-treated and intoxicated rats was reduced as compared with intoxicated control rats. The same effect was found when malotilate (100 mg/kg, p.o., 5 days per week), was given for 3 weeks to rats already intoxicated during the 6 previous weeks. Malotilate was able to prevent the increase of hepatic alterations that appeared during the last 3 weeks of CCl
4 intoxication. These results show clearly that malotilate can markedly reduce the hepatic disorders induced by a chronic CCl
4 intoxication in the rat.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>3794306</pmid><doi>10.1016/S0168-8278(86)80036-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 1986, Vol.3 (2), p.260-268 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00313357v1 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biochemistry, Molecular Biology Biological and medical sciences Body Weight - drug effects Carbon Tetrachloride Chronic Disease Collagen - biosynthesis Digestive system Life Sciences Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Male Malonates - therapeutic use Medical sciences Organ Size - drug effects Pharmacology. Drug treatments Rats |
| title | Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T07%3A10%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20malotilate%20on%20chronic%20liver%20injury%20induced%20by%20carbon%20tetrachloride%20in%20the%20rat&rft.jtitle=Journal%20of%20hepatology&rft.au=Dumont,%20J.-M.&rft.date=1986&rft.volume=3&rft.issue=2&rft.spage=260&rft.epage=268&rft.pages=260-268&rft.issn=0168-8278&rft.eissn=1600-0641&rft.coden=JOHEEC&rft_id=info:doi/10.1016/S0168-8278(86)80036-8&rft_dat=%3Celsevier_hal_p%3ES0168827886800368%3C/elsevier_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3794306&rft_els_id=S0168827886800368&rfr_iscdi=true |