The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of p...
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| Veröffentlicht in: | Development (Cambridge) 2003-02, Vol.130 (4), p.763-774 |
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| creator | Fanto, Manolis Clayton, Lesley Meredith, Jamie Hardiman, Kirsten Charroux, Bernard Kerridge, Stephen McNeill, Helen |
| description | Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of planar polarity. We show that Atrophin binds to the cytoplasmic domain of Fat and that Atrophin mutants show strong genetic interactions with fat . We find that both Atrophin and fat clones in the eye have non-autonomous disruptions in planar polarity that are restricted to the polar border of clones and that there is rescue of planar polarity defects on the equatorial border of these clones. Both fat and Atrophin are required to control four-jointed expression. In addition our mosaic analysis demonstrates an enhanced requirement for Atrophin in the R3 photoreceptor. These data lead us to a model in which fat and Atrophin act twice in the determination of planar polarity in the eye: first in setting up positional information through the production of a planar polarity diffusible signal, and later in R3 fate determination. |
| doi_str_mv | 10.1242/dev.00304 |
| format | Article |
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Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of planar polarity. We show that Atrophin binds to the cytoplasmic domain of Fat and that Atrophin mutants show strong genetic interactions with fat . We find that both Atrophin and fat clones in the eye have non-autonomous disruptions in planar polarity that are restricted to the polar border of clones and that there is rescue of planar polarity defects on the equatorial border of these clones. Both fat and Atrophin are required to control four-jointed expression. In addition our mosaic analysis demonstrates an enhanced requirement for Atrophin in the R3 photoreceptor. These data lead us to a model in which fat and Atrophin act twice in the determination of planar polarity in the eye: first in setting up positional information through the production of a planar polarity diffusible signal, and later in R3 fate determination.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.00304</identifier><identifier>PMID: 12506006</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Animals ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Cell Differentiation ; Cell Nucleus - genetics ; Cell Nucleus - metabolism ; Cell Polarity ; Cellular Biology ; Cytoplasm - genetics ; Cytoplasm - metabolism ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Eye - cytology ; Eye - growth & development ; Eye - metabolism ; Eye Abnormalities - genetics ; Eye Abnormalities - pathology ; Female ; Gene Expression Regulation, Developmental ; Genes, Tumor Suppressor ; Life Sciences ; Male ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Mutation ; Photoreceptor Cells, Invertebrate - metabolism ; Protein Structure, Tertiary ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic</subject><ispartof>Development (Cambridge), 2003-02, Vol.130 (4), p.763-774</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-59c185bb7b4782b4561e858dc46fe9b39af159e685482f8bf0cc476c8b8d649b3</citedby><cites>FETCH-LOGICAL-c418t-59c185bb7b4782b4561e858dc46fe9b39af159e685482f8bf0cc476c8b8d649b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12506006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00310888$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fanto, Manolis</creatorcontrib><creatorcontrib>Clayton, Lesley</creatorcontrib><creatorcontrib>Meredith, Jamie</creatorcontrib><creatorcontrib>Hardiman, Kirsten</creatorcontrib><creatorcontrib>Charroux, Bernard</creatorcontrib><creatorcontrib>Kerridge, Stephen</creatorcontrib><creatorcontrib>McNeill, Helen</creatorcontrib><title>The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of planar polarity. We show that Atrophin binds to the cytoplasmic domain of Fat and that Atrophin mutants show strong genetic interactions with fat . We find that both Atrophin and fat clones in the eye have non-autonomous disruptions in planar polarity that are restricted to the polar border of clones and that there is rescue of planar polarity defects on the equatorial border of these clones. Both fat and Atrophin are required to control four-jointed expression. In addition our mosaic analysis demonstrates an enhanced requirement for Atrophin in the R3 photoreceptor. 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Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of planar polarity. We show that Atrophin binds to the cytoplasmic domain of Fat and that Atrophin mutants show strong genetic interactions with fat . We find that both Atrophin and fat clones in the eye have non-autonomous disruptions in planar polarity that are restricted to the polar border of clones and that there is rescue of planar polarity defects on the equatorial border of these clones. Both fat and Atrophin are required to control four-jointed expression. In addition our mosaic analysis demonstrates an enhanced requirement for Atrophin in the R3 photoreceptor. 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| ispartof | Development (Cambridge), 2003-02, Vol.130 (4), p.763-774 |
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| recordid | cdi_hal_primary_oai_HAL_hal_00310888v1 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Differentiation Cell Nucleus - genetics Cell Nucleus - metabolism Cell Polarity Cellular Biology Cytoplasm - genetics Cytoplasm - metabolism Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye - cytology Eye - growth & development Eye - metabolism Eye Abnormalities - genetics Eye Abnormalities - pathology Female Gene Expression Regulation, Developmental Genes, Tumor Suppressor Life Sciences Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mutation Photoreceptor Cells, Invertebrate - metabolism Protein Structure, Tertiary Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| title | The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor |
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