Genome-wide RNA polymerase II: not genes only
RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Po...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2008-06, Vol.33 (6), p.265-273 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Koch, Frederic Jourquin, Frederic Ferrier, Pierre Andrau, Jean-Christophe |
| description | RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early
in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Pol II should essentially be located on promoters or genic regions of transcribed genes. The development of
in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy. Recent studies from yeast to human show that Pol II can be poised at the transcription start site or can be located outside of gene-coding regions, sometimes dependent on the growth or differentiation stage. These recent results regarding Pol II genomic location and transcription challenge our classical views of transcriptional regulation. |
| doi_str_mv | 10.1016/j.tibs.2008.04.006 |
| format | Article |
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in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Pol II should essentially be located on promoters or genic regions of transcribed genes. The development of
in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy. Recent studies from yeast to human show that Pol II can be poised at the transcription start site or can be located outside of gene-coding regions, sometimes dependent on the growth or differentiation stage. These recent results regarding Pol II genomic location and transcription challenge our classical views of transcriptional regulation.</description><identifier>ISSN: 0968-0004</identifier><identifier>EISSN: 1362-4326</identifier><identifier>DOI: 10.1016/j.tibs.2008.04.006</identifier><identifier>PMID: 18467100</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biological Transport, Active ; Bucladesine ; Calcium ; Calcium-Transporting ATPases ; Carrier Proteins ; Cell Membrane ; Gene Expression Regulation - physiology ; Genome, Fungal - physiology ; Genome, Human - physiology ; Humans ; Immunology ; Kidney Cortex ; Kidney Tubules, Distal ; Kidney Tubules, Proximal ; Kinetics ; Life Sciences ; Parathyroid Hormone ; Promoter Regions, Genetic - physiology ; Rabbits ; RNA Polymerase II - metabolism ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - metabolism ; Sodium-Calcium Exchanger ; Tetradecanoylphorbol Acetate ; Transcription, Genetic - physiology</subject><ispartof>Trends in biochemical sciences (Amsterdam. Regular ed.), 2008-06, Vol.33 (6), p.265-273</ispartof><rights>2008 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-7dc9f0046c82eacf4d80f05a4cc76af332007f1a7cc1c4b1f931a83a5ee986d83</citedby><cites>FETCH-LOGICAL-c419t-7dc9f0046c82eacf4d80f05a4cc76af332007f1a7cc1c4b1f931a83a5ee986d83</cites><orcidid>0000-0003-0203-8507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tibs.2008.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18467100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00294059$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Koch, Frederic</creatorcontrib><creatorcontrib>Jourquin, Frederic</creatorcontrib><creatorcontrib>Ferrier, Pierre</creatorcontrib><creatorcontrib>Andrau, Jean-Christophe</creatorcontrib><title>Genome-wide RNA polymerase II: not genes only</title><title>Trends in biochemical sciences (Amsterdam. Regular ed.)</title><addtitle>Trends Biochem Sci</addtitle><description>RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early
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in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy. Recent studies from yeast to human show that Pol II can be poised at the transcription start site or can be located outside of gene-coding regions, sometimes dependent on the growth or differentiation stage. 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| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2008-06, Vol.33 (6), p.265-273 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological Transport, Active Bucladesine Calcium Calcium-Transporting ATPases Carrier Proteins Cell Membrane Gene Expression Regulation - physiology Genome, Fungal - physiology Genome, Human - physiology Humans Immunology Kidney Cortex Kidney Tubules, Distal Kidney Tubules, Proximal Kinetics Life Sciences Parathyroid Hormone Promoter Regions, Genetic - physiology Rabbits RNA Polymerase II - metabolism Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Sodium-Calcium Exchanger Tetradecanoylphorbol Acetate Transcription, Genetic - physiology |
| title | Genome-wide RNA polymerase II: not genes only |
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