Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery

Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or α-p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehyd...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-05, Vol.130 (21), p.6774-6780
Hauptverfasser:	Horcajada, Patricia, Serre, Christian, Maurin, Guillaume, Ramsahye, Naseem A, Balas, Francisco, Vallet-Regí, María, Sebban, Muriel, Taulelle, Francis, Férey, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Chemical Physics Chromium Compounds - administration & dosage Chromium Compounds - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Ferric Compounds - administration & dosage Ferric Compounds - chemistry Ibuprofen - administration & dosage Ibuprofen - chemistry Kinetics Magnetic Resonance Spectroscopy - methods Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Models, Molecular Phthalic Acids - administration & dosage Phthalic Acids - chemistry Physics Spectroscopy, Fourier Transform Infrared X-Ray Diffraction
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