Pinpointing a selective sweep to the chimpanzee MHC class I region by comparative genomics

Chimpanzees experienced a reduction of the allelic repertoire at the major histocompatibility complex (MHC) class I A and B loci, which may have been caused by a retrovirus belonging to the simian immunodeficiency virus (SIV) family. Extended MHC haplotypes were defined in a pedigreed chimpanzee col...

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Veröffentlicht in:	Molecular ecology 2008-04, Vol.17 (8), p.2074-2088
Hauptverfasser:	DE GROOT, NATASJA G, HEIJMANS, CORRINE M.C, DE GROOT, NANINE, OTTING, NEL, DE VOS-ROUWELER, ANNEMIEK J.M, REMARQUE, EDMOND J, BONHOMME, MAXIME, DOXIADIS, GABY G.M, CROUAU-ROY, BRIGITTE, BONTROP, RONALD E
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa, Western Animal biology Animals Biodiversity Comparative studies DNA, Mitochondrial - chemistry DNA, Mitochondrial - genetics Ecology Ecology, environment Genetic Variation Genetics Genomics haplotypes Haplotypes - genetics Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HIV Humans Life Sciences microsatellite microsatellite repeats Microsatellite Repeats - genetics Molecular biology Pan troglodytes Pan troglodytes - genetics Pan troglodytes - immunology Phylogeny Polymerase Chain Reaction primate evolution Primates selection Sequence Analysis, DNA Simian immunodeficiency virus
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