Lobular — but not periovular — inhibition of collagen deposition in the liver of S. Mansoni infected mice using interferon-γ

Background/Aims: Interferon-γ (IFNγ) elicits antiproliferative and antifibrogenic activity in a variety of mesenchymal cells, including hepatic stellate cells (Ito cells), and therefore represents a possible drug for liver fibrosis. However, IFNγ binds to heparan sulfate, and is localized by these m...

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Veröffentlicht in:	Journal of hepatology 1997-04, Vol.26 (4), p.894-903
Hauptverfasser:	Lortat-Jacob, Hugues, Baltzer, Frederic, Desmoulière, Alexis, Peyrol, Simone, Grimaud, Jean-Alexis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents Biochemistry, Molecular Biology Biological and medical sciences Collagen Collagen - immunology Collagen - metabolism Diseases caused by trematodes Female Fibrosis Granuloma Granuloma - metabolism Granuloma - pathology Helminthic diseases Heparan sulfate Immunomodulators Infectious diseases Interferon Interferon Type II Interferon-gamma - pharmacology Interferon-gamma, Recombinant Life Sciences Liver Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental Liver Cirrhosis, Experimental - parasitology Liver Diseases, Parasitic Liver Diseases, Parasitic - metabolism Liver Diseases, Parasitic - pathology Medical sciences Mice Microscopy, Electron Parasitic diseases Pharmacology. Drug treatments Recombinant Proteins Reference Values Schistosomiases Schistosomiasis mansoni Schistosomiasis mansoni - complications Schistosomiasis mansoni - metabolism Schistosomiasis mansoni - pathology Tissue Distribution
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