Structure−Activity Relationships of Phenyl-Furanyl-Rhodanines as Inhibitors of RNA Polymerase with Antibacterial Activity on Biofilms

The dramatic rise of antibiotic-resistant bacteria over the past two decades has stressed the need for completely novel classes of antibacterial agents. Accordingly, recent advances in the study of prokaryotic transcription open new opportunities for such molecules. This paper reports the structure−...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-08, Vol.50 (17), p.4195-4204
Hauptverfasser:	Villain-Guillot, Philippe, Gualtieri, Maxime, Bastide, Lionel, Roquet, Françoise, Martinez, Jean, Amblard, Muriel, Pugniere, Martine, Leonetti, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biofilms Biological and medical sciences Cellular Biology CHO Cells Cricetinae Cricetulus DNA-Directed RNA Polymerases DNA-Directed RNA Polymerases - antagonists & inhibitors Escherichia coli Furans Furans - chemical synthesis Furans - pharmacology Gram-Positive Bacteria Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - isolation & purification Gram-Positive Bacteria - physiology Life Sciences Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Rhodanine Rhodanine - analogs & derivatives Rhodanine - chemical synthesis Rhodanine - pharmacology Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Staphylococcus epidermidis - isolation & purification Staphylococcus epidermidis - physiology Structure-Activity Relationship
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