Exploring functional genomics for drug target and therapeutics discovery in Plasmodia
Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. N...
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| Veröffentlicht in: | Acta tropica 2008-02, Vol.105 (2), p.113-123 |
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| container_title | Acta tropica |
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| creator | Birkholtz, L. van Brummelen, A.C. Clark, K. Niemand, J. Maréchal, E. Llinás, M. Louw, A.I. |
| description | Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of
Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the
Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the
status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the
in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics. |
| doi_str_mv | 10.1016/j.actatropica.2007.10.013 |
| format | Article |
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Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the
Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the
status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the
in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2007.10.013</identifier><identifier>PMID: 18083131</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Drug Design ; Drug target ; Functional genomics ; Gene Expression Profiling ; General aspects ; Genomics ; Human protozoal diseases ; Humans ; Infectious diseases ; Interactome ; Life Sciences ; Malaria ; Malaria - drug therapy ; Malaria - parasitology ; Medical sciences ; Oligonucleotide Array Sequence Analysis ; Parasitic diseases ; Plasmodium ; Plasmodium - drug effects ; Proteome ; Protozoal diseases ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Therapeutics ; Transcriptome</subject><ispartof>Acta tropica, 2008-02, Vol.105 (2), p.113-123</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-a9584d9f5556e563b21a42f47289376e91b55044db88caeb8acf8c4a3f772a723</citedby><cites>FETCH-LOGICAL-c521t-a9584d9f5556e563b21a42f47289376e91b55044db88caeb8acf8c4a3f772a723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actatropica.2007.10.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20077719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18083131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00250161$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Birkholtz, L.</creatorcontrib><creatorcontrib>van Brummelen, A.C.</creatorcontrib><creatorcontrib>Clark, K.</creatorcontrib><creatorcontrib>Niemand, J.</creatorcontrib><creatorcontrib>Maréchal, E.</creatorcontrib><creatorcontrib>Llinás, M.</creatorcontrib><creatorcontrib>Louw, A.I.</creatorcontrib><title>Exploring functional genomics for drug target and therapeutics discovery in Plasmodia</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of
Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the
Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the
status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the
in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.</description><subject>Animals</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Drug Design</subject><subject>Drug target</subject><subject>Functional genomics</subject><subject>Gene Expression Profiling</subject><subject>General aspects</subject><subject>Genomics</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interactome</subject><subject>Life Sciences</subject><subject>Malaria</subject><subject>Malaria - drug therapy</subject><subject>Malaria - parasitology</subject><subject>Medical sciences</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Parasitic diseases</subject><subject>Plasmodium</subject><subject>Plasmodium - drug effects</subject><subject>Proteome</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - metabolism</subject><subject>Therapeutics</subject><subject>Transcriptome</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9r3DAQxUVpaDZpv0JxDy3k4K3-WJZ9DEuaFBbSQwO9ibE83mixLVeSl-TbV2aXNLf2NMzoN6PHe4R8YnTNKCu_7tdgIkTvJmtgzSlVab6mTLwhK1YpkZdcFm_JilLKckXLX-fkIoR96riS_B05ZxWtBBNsRR5unqbeeTvusm4eTbRuhD7b4egGa0LWOZ-1ft5lEfwOYwZjm8VH9DDhHBegtcG4A_rnzI7Zjx7C4FoL78lZB33AD6d6SR6-3fzc3OXb-9vvm-ttbiRnMYdaVkVbd1LKEmUpGs6g4F2heFULVWLNGilpUbRNVRnApgLTVaYA0SnFQXFxSa6Odx-h15O3A_hn7cDqu-utXmaUcpkcYweW2C9HdvLu94wh6iFpx76HEd0ctEoo47X6JyiSibTkIoH1ETTeheCxe5HAqF6C0nv9Kii9BLU8paDS7sfTJ3MzYPt385RMAj6fAAgG-s7DaGx44ZZbSrE6cZsjh8nng0Wvg7E4GmytRxN16-x_yPkDsIS2zQ</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Birkholtz, L.</creator><creator>van Brummelen, A.C.</creator><creator>Clark, K.</creator><creator>Niemand, J.</creator><creator>Maréchal, E.</creator><creator>Llinás, M.</creator><creator>Louw, A.I.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20080201</creationdate><title>Exploring functional genomics for drug target and therapeutics discovery in Plasmodia</title><author>Birkholtz, L. ; 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However, the application of functional genomics to post-genomics research of
Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the
Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the
status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the
in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18083131</pmid><doi>10.1016/j.actatropica.2007.10.013</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antimalarials - pharmacology Antimalarials - therapeutic use Biochemistry, Molecular Biology Biological and medical sciences Drug Design Drug target Functional genomics Gene Expression Profiling General aspects Genomics Human protozoal diseases Humans Infectious diseases Interactome Life Sciences Malaria Malaria - drug therapy Malaria - parasitology Medical sciences Oligonucleotide Array Sequence Analysis Parasitic diseases Plasmodium Plasmodium - drug effects Proteome Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - metabolism Therapeutics Transcriptome |
| title | Exploring functional genomics for drug target and therapeutics discovery in Plasmodia |
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