LRRK2 G2019S as a Cause of Parkinson's Disease in North African Arabs

To the Editor: Parkinson's disease is characterized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, a good response to levodopa, and the presence of Lewy bodies. The recently identified G2019S mutation in exon 41 of the leucine-r...

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Veröffentlicht in:	The New England journal of medicine 2006-01, Vol.354 (4), p.422-423
Hauptverfasser:	Tazir, Meriem, Pollak, Pierre, Lesage, Suzanne, Lohmann, Ebba, Brice, Alexis, Dürr, Alexandra, Leutenegger, Anne-Louise, Janin, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa, Northern Africa, Northern - ethnology Arabs Arabs - genetics Heterozygote Homozygote Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Life Sciences Middle Aged Mutation Neurons and Cognition Parkinson Disease Parkinson Disease - genetics Parkinson's disease Protein-Serine-Threonine Kinases Protein-Serine-Threonine Kinases - genetics
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