M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2–Sos association and phosphatidylinositol 3-kinase activity

Macrophage colony-stimulating factor (M-CSF) is a physiological regulator of monocyte–macrophage lineage. Ectopic expression of the M-CSF receptor (M-CSFR, or Fms) in murine myeloid cell line FDC-P1 (FD/Fms cells) results in M-CSF-dependent macrophage differentiation. Previously, we observed that M-...

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Veröffentlicht in:	Cellular signalling 2005-11, Vol.17 (11), p.1352-1362
Hauptverfasser:	Gobert Gosse, Stéphanie, Bourgin, Caroline, Liu, Wang Qing, Garbay, Christiane, Mouchiroud, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-Kinase Animals Butadienes Butadienes - pharmacology Cell Line Chromones Chromones - pharmacology Grb2 GRB2 Adaptor Protein GRB2 Adaptor Protein - metabolism Life Sciences Macrophage Colony-Stimulating Factor Macrophage Colony-Stimulating Factor - physiology Macrophage differentiation Macrophages Macrophages - cytology Macrophages - metabolism MAP kinase MAP Kinase Kinase 1 MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism MAP Kinase Signaling System Mice Morpholines Morpholines - pharmacology Myeloid Progenitor Cells Myeloid Progenitor Cells - cytology Myeloid Progenitor Cells - metabolism Nitriles Nitriles - pharmacology Phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Binding Receptor, Macrophage Colony-Stimulating Factor Receptor, Macrophage Colony-Stimulating Factor - metabolism Son of Sevenless Protein, Drosophila Son of Sevenless Protein, Drosophila - metabolism Vegetal Biology
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