Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function

Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPARalpha) activation modulates LC function. Our results show that PPARalpha is expressed i...

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Veröffentlicht in:	Journal of Immunology 2007-04, Vol.178 (7), p.4362-4372
Hauptverfasser:	Dubrac, Sandrine, Stoitzner, Patrizia, Pirkebner, Daniela, Elentner, Andreas, Schoonjans, Kristina, Auwerx, Johan, Saeland, Sem, Hengster, Paul, Fritsch, Peter, Romani, Nikolaus, Schmuth, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Cell Movement Cell Nucleus Cell Nucleus - metabolism Cell Proliferation Cytokines Cytokines - metabolism Langerhans Cells Langerhans Cells - chemistry Langerhans Cells - immunology Life Sciences Lymph Nodes Lymph Nodes - cytology Lymph Nodes - immunology MAP Kinase Kinase 4 MAP Kinase Kinase 4 - metabolism Mice Mice, Inbred Strains Mice, Mutant Strains Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 3 - metabolism Molecular biology p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation PPAR alpha PPAR alpha - analysis PPAR alpha - genetics PPAR alpha - metabolism Pyrimidines Pyrimidines - pharmacology Skin Skin - cytology Skin - immunology T-Lymphocytes T-Lymphocytes - immunology Transcription Factor RelA Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - metabolism
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