Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Turn up the heat Bile acids are known to mediate dietary lipid absorption and cholesterol catabolism, and recently an important signalling role emerged. Now they have been found to increase energy expenditure in brown adipose tissue and human skeletal muscle. As bile acid signalling may drive diet-i...

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Veröffentlicht in:	Nature 2006-01, Vol.439 (7075), p.484-489
Hauptverfasser:	Watanabe, Mitsuhiro, Houten, Sander M., Mataki, Chikage, Christoffolete, Marcelo A., Kim, Brian W., Sato, Hiroyuki, Messaddeq, Nadia, Harney, John W., Ezaki, Osamu, Kodama, Tatsuhiko, Schoonjans, Kristina, Bianco, Antonio C., Auwerx, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Adipose tissue Adipose Tissue, Brown Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - enzymology Adipose Tissue, Brown - metabolism Adiposity Adiposity - drug effects Animals Bile Bile Acids and Salts Bile Acids and Salts - pharmacology Biochemistry, Molecular Biology Biological and medical sciences Biosynthesis Body Weight Body Weight - drug effects Carbon Dioxide Carbon Dioxide - metabolism Cholesterol Cholic Acid Cholic Acid - pharmacology Cyclic AMP Cyclic AMP - biosynthesis Dietary Fats Dietary Fats - administration & dosage Dietary Fats - pharmacology Energy Metabolism Energy Metabolism - drug effects Fatty acids Fundamental and applied biological sciences. Psychology Gene Deletion Gene expression Homeostasis Homeostasis - drug effects Hormones Humanities and Social Sciences Humans Insulin Iodide Peroxidase Iodide Peroxidase - deficiency Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II letter Life Sciences Liver Liver - drug effects Liver - metabolism Liver. Bile. Biliary tracts Metabolism Mice Mice, Inbred C57BL Molecular biology multidisciplinary Muscle Cells Muscle Cells - drug effects Muscle Cells - enzymology Muscle Cells - metabolism Muscle, Skeletal Muscle, Skeletal - cytology Obesity Oxygen Consumption Oxygen Consumption - drug effects Receptors, G-Protein-Coupled Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Rodents Science Science (multidisciplinary) Thyroid Thyroid gland Thyroid Hormones Thyroid Hormones - metabolism Vertebrates: digestive system Weight control
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