Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons

Retinoic acid (RA) activity plays sequential roles during the development of the ventral spinal cord. Here, we have investigated the functions of local RA synthesis in the process of motoneuron specification and early differentiation using a conditional knockout strategy that ablates the function of...

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Veröffentlicht in:	Development (Cambridge) 2005-04, Vol.132 (7), p.1611-1621
Hauptverfasser:	Vermot, Julien, Schuhbaur, Brigitte, Le Mouellic, Hervé, McCaffery, Peter, Garnier, Jean-Marie, Hentsch, Didier, Brûlet, Philippe, Niederreither, Karen, Chambon, Pierre, Dollé, Pascal, Le Roux, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidoreductases Aldehyde Oxidoreductases - genetics Aldehyde Oxidoreductases - metabolism Animals Biochemistry, Molecular Biology Homeodomain Proteins Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Life Sciences LIM-Homeodomain Proteins Mice Mice, Knockout Molecular biology Motor Neurons Motor Neurons - metabolism Mutation Spinal Cord Spinal Cord - embryology Spinal Cord - metabolism Transcription Factors Transcription Factors - metabolism
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