Calcium transients and neurotransmitter release at an identified synapse
It is widely accepted that the modulation of the presynaptic Ca2+ influx is one of the main mechanisms by which neurotransmitter release can be controlled. The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ tr...
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| Veröffentlicht in: | Trends in Neurosciences 1999-04, Vol.22 (4), p.161-166 |
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| creator | Fossier, Philippe Tauc, Ladislav Baux, Gérard |
| description | It is widely accepted that the modulation of the presynaptic Ca2+ influx is one of the main mechanisms by which neurotransmitter release can be controlled. The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ transients and to relate this to quantal evoked neurotransmitter release. Three types of Ca2+ channel (L, N and P) are present in the presynaptic neurone at this synapse. Influxes of Ca2+ through N- and P-type channels trigger the release of ACh with only N-type Ca2+ channels being regulated by presynaptic neuromodulator receptors. In addition, presynaptic Ca2+ stores, via complex mechanisms of Ca2+ uptake and Ca2+ release, control the Ca2+ concentration that triggers this evoked ACh release. |
| doi_str_mv | 10.1016/S0166-2236(98)01307-1 |
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The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ transients and to relate this to quantal evoked neurotransmitter release. Three types of Ca2+ channel (L, N and P) are present in the presynaptic neurone at this synapse. Influxes of Ca2+ through N- and P-type channels trigger the release of ACh with only N-type Ca2+ channels being regulated by presynaptic neuromodulator receptors. In addition, presynaptic Ca2+ stores, via complex mechanisms of Ca2+ uptake and Ca2+ release, control the Ca2+ concentration that triggers this evoked ACh release.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/S0166-2236(98)01307-1</identifier><identifier>PMID: 10203853</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetylcholine ; Acetylcholine - secretion ; Acetylcholine release ; Adenosine Diphosphate Ribose ; Adenosine Diphosphate Ribose - analogs & derivatives ; Adenosine Diphosphate Ribose - physiology ; ADPRibose ; Animals ; Aplysia ; Aplysia - physiology ; ATP-dependent calcium pump ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; Calcium ; Calcium - metabolism ; Calcium Channels ; Calcium Channels - classification ; Calcium Channels - physiology ; Calcium Signaling ; Calcium Signaling - physiology ; Calcium stores ; Cyclic ; Cyclic ADP-Ribose ; Fundamental and applied biological sciences. Psychology ; Ganglia, Invertebrate ; Ganglia, Invertebrate - physiology ; Invertebrates ; Ion Transport ; Life Sciences ; Models, Neurological ; Mollusca ; Nerve Tissue Proteins ; Nerve Tissue Proteins - physiology ; Neurons and Cognition ; Organelles ; Organelles - secretion ; Physiology. Development ; Presynaptic receptors ; Presynaptic Terminals ; Presynaptic Terminals - physiology ; Ryanodine receptors ; Voltage-gated calcium channels</subject><ispartof>Trends in Neurosciences, 1999-04, Vol.22 (4), p.161-166</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-32713b01978d58ec5bfd7310729666f9ddb27423b15c71dbc042827c11b3f7e63</citedby><cites>FETCH-LOGICAL-c455t-32713b01978d58ec5bfd7310729666f9ddb27423b15c71dbc042827c11b3f7e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-2236(98)01307-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,313,314,780,784,792,885,3550,27922,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1783391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10203853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00171932$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fossier, Philippe</creatorcontrib><creatorcontrib>Tauc, Ladislav</creatorcontrib><creatorcontrib>Baux, Gérard</creatorcontrib><title>Calcium transients and neurotransmitter release at an identified synapse</title><title>Trends in Neurosciences</title><addtitle>Trends Neurosci</addtitle><description>It is widely accepted that the modulation of the presynaptic Ca2+ influx is one of the main mechanisms by which neurotransmitter release can be controlled. The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ transients and to relate this to quantal evoked neurotransmitter release. Three types of Ca2+ channel (L, N and P) are present in the presynaptic neurone at this synapse. Influxes of Ca2+ through N- and P-type channels trigger the release of ACh with only N-type Ca2+ channels being regulated by presynaptic neuromodulator receptors. In addition, presynaptic Ca2+ stores, via complex mechanisms of Ca2+ uptake and Ca2+ release, control the Ca2+ concentration that triggers this evoked ACh release.</description><subject>Acetylcholine</subject><subject>Acetylcholine - secretion</subject><subject>Acetylcholine release</subject><subject>Adenosine Diphosphate Ribose</subject><subject>Adenosine Diphosphate Ribose - analogs & derivatives</subject><subject>Adenosine Diphosphate Ribose - physiology</subject><subject>ADPRibose</subject><subject>Animals</subject><subject>Aplysia</subject><subject>Aplysia - physiology</subject><subject>ATP-dependent calcium pump</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels</subject><subject>Calcium Channels - classification</subject><subject>Calcium Channels - physiology</subject><subject>Calcium Signaling</subject><subject>Calcium Signaling - physiology</subject><subject>Calcium stores</subject><subject>Cyclic</subject><subject>Cyclic ADP-Ribose</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Invertebrate</subject><subject>Ganglia, Invertebrate - physiology</subject><subject>Invertebrates</subject><subject>Ion Transport</subject><subject>Life Sciences</subject><subject>Models, Neurological</subject><subject>Mollusca</subject><subject>Nerve Tissue Proteins</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neurons and Cognition</subject><subject>Organelles</subject><subject>Organelles - secretion</subject><subject>Physiology. Development</subject><subject>Presynaptic receptors</subject><subject>Presynaptic Terminals</subject><subject>Presynaptic Terminals - physiology</subject><subject>Ryanodine receptors</subject><subject>Voltage-gated calcium channels</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERbeFnwDKAaH2kOKx44-cULUCttJKPQASN8uxJ8IoH4udVOq_x9msCrdePNL48fid9yXkLdAboCA_fsuHLBnj8qrW1xQ4VSW8IBvQSpdA9c-XZPOEnJOLlH5TCpWG6hU5B8oo14JvyG5rOxfmvpiiHVLAYUqFHXwx4BzHY68P04SxiNihTVjYKd8XwWcytAF9kR4He0j4mpy1tkv45lQvyY8vn79vd-X-_uvd9nZfukqIqeRMAW8o1Ep7odGJpvWKA1WsllK2tfcNUxXjDQinwDeOVkwz5QAa3iqU_JJcr3N_2c4cYuhtfDSjDWZ3uzdLL2-poObsATL7YWUPcfwzY5pMH5LDrrMDjnMyspY1zx49C4LitBJcZFCsoItjShHbJwlAzZKLOeZiFtNNrc0xF7MoeXf6YG569P-9WoPIwPsTYJOzXZuddyH945TmvF7mfFoxzBY_BIwmuRyaQx8iusn4MTyj5C_pBafQ</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Fossier, Philippe</creator><creator>Tauc, Ladislav</creator><creator>Baux, Gérard</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19990401</creationdate><title>Calcium transients and neurotransmitter release at an identified synapse</title><author>Fossier, Philippe ; Tauc, Ladislav ; Baux, Gérard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-32713b01978d58ec5bfd7310729666f9ddb27423b15c71dbc042827c11b3f7e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - secretion</topic><topic>Acetylcholine release</topic><topic>Adenosine Diphosphate Ribose</topic><topic>Adenosine Diphosphate Ribose - analogs & derivatives</topic><topic>Adenosine Diphosphate Ribose - physiology</topic><topic>ADPRibose</topic><topic>Animals</topic><topic>Aplysia</topic><topic>Aplysia - physiology</topic><topic>ATP-dependent calcium pump</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels</topic><topic>Calcium Channels - classification</topic><topic>Calcium Channels - physiology</topic><topic>Calcium Signaling</topic><topic>Calcium Signaling - physiology</topic><topic>Calcium stores</topic><topic>Cyclic</topic><topic>Cyclic ADP-Ribose</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Invertebrate</topic><topic>Ganglia, Invertebrate - physiology</topic><topic>Invertebrates</topic><topic>Ion Transport</topic><topic>Life Sciences</topic><topic>Models, Neurological</topic><topic>Mollusca</topic><topic>Nerve Tissue Proteins</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neurons and Cognition</topic><topic>Organelles</topic><topic>Organelles - secretion</topic><topic>Physiology. Development</topic><topic>Presynaptic receptors</topic><topic>Presynaptic Terminals</topic><topic>Presynaptic Terminals - physiology</topic><topic>Ryanodine receptors</topic><topic>Voltage-gated calcium channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fossier, Philippe</creatorcontrib><creatorcontrib>Tauc, Ladislav</creatorcontrib><creatorcontrib>Baux, Gérard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Trends in Neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fossier, Philippe</au><au>Tauc, Ladislav</au><au>Baux, Gérard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium transients and neurotransmitter release at an identified synapse</atitle><jtitle>Trends in Neurosciences</jtitle><addtitle>Trends Neurosci</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>22</volume><issue>4</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><abstract>It is widely accepted that the modulation of the presynaptic Ca2+ influx is one of the main mechanisms by which neurotransmitter release can be controlled. The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ transients and to relate this to quantal evoked neurotransmitter release. Three types of Ca2+ channel (L, N and P) are present in the presynaptic neurone at this synapse. Influxes of Ca2+ through N- and P-type channels trigger the release of ACh with only N-type Ca2+ channels being regulated by presynaptic neuromodulator receptors. In addition, presynaptic Ca2+ stores, via complex mechanisms of Ca2+ uptake and Ca2+ release, control the Ca2+ concentration that triggers this evoked ACh release.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10203853</pmid><doi>10.1016/S0166-2236(98)01307-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetylcholine Acetylcholine - secretion Acetylcholine release Adenosine Diphosphate Ribose Adenosine Diphosphate Ribose - analogs & derivatives Adenosine Diphosphate Ribose - physiology ADPRibose Animals Aplysia Aplysia - physiology ATP-dependent calcium pump Biochemistry. Physiology. Immunology Biological and medical sciences Calcium Calcium - metabolism Calcium Channels Calcium Channels - classification Calcium Channels - physiology Calcium Signaling Calcium Signaling - physiology Calcium stores Cyclic Cyclic ADP-Ribose Fundamental and applied biological sciences. Psychology Ganglia, Invertebrate Ganglia, Invertebrate - physiology Invertebrates Ion Transport Life Sciences Models, Neurological Mollusca Nerve Tissue Proteins Nerve Tissue Proteins - physiology Neurons and Cognition Organelles Organelles - secretion Physiology. Development Presynaptic receptors Presynaptic Terminals Presynaptic Terminals - physiology Ryanodine receptors Voltage-gated calcium channels |
| title | Calcium transients and neurotransmitter release at an identified synapse |
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