Effects of high hydrostatic pressure on several sensitive therapeutic molecules and a soft nanodispersed drug delivery system
According to the development in the last decade of industrial processes using high hydrostatic pressure (HHP) for preservation of several commercial food products, novel sterilization or decontamination processes for pharmaceutical products could be conceivable. The aim of this work is to evaluate t...
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| Veröffentlicht in: | Pharmaceutical research 2003-12, Vol.20 (12), p.2036-2040 |
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| creator | RIGALDIE, Yohan LARGETEAU, Alain LEMAGNEN, Gilles IBALOT, Fabienne PARDON, Patrick DEMAZEAU, Gérard GRISLAIN, Luc |
| description | According to the development in the last decade of industrial processes using high hydrostatic pressure (HHP) for preservation of several commercial food products, novel sterilization or decontamination processes for pharmaceutical products could be conceivable. The aim of this work is to evaluate the effects of HHP on the integrity of insulin and heparin solutions, suspension of monoclonal antibodies and Spherulites.
High performance liquid chromatography, thin layer chromatography, capillary electrophoresis assays, ELISA tests, laser granulometry and spectrophotometry analyses have been performed to compare HHP treated drugs (in a domain of pressure and temperature ranging respectively from 20 up to 500 MPa and from 20 degrees C up to 37 degrees C) vs. untreated ones.
No difference has been detected except for monoclonal antibodies that are altered above 500 MPa.
The structure integrity of sensitive molecule due to the small energy involved by HHP and the development of industrial plants (intended for the decontamination of food products) confer to this technology the potential of a new method for sterilization of fragile drugs and an original alternative to aseptic processes and sterilizing filtration. |
| doi_str_mv | 10.1023/B:PHAM.0000008054.80136.5a |
| format | Article |
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High performance liquid chromatography, thin layer chromatography, capillary electrophoresis assays, ELISA tests, laser granulometry and spectrophotometry analyses have been performed to compare HHP treated drugs (in a domain of pressure and temperature ranging respectively from 20 up to 500 MPa and from 20 degrees C up to 37 degrees C) vs. untreated ones.
No difference has been detected except for monoclonal antibodies that are altered above 500 MPa.
The structure integrity of sensitive molecule due to the small energy involved by HHP and the development of industrial plants (intended for the decontamination of food products) confer to this technology the potential of a new method for sterilization of fragile drugs and an original alternative to aseptic processes and sterilizing filtration.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/B:PHAM.0000008054.80136.5a</identifier><identifier>PMID: 14725371</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Antibodies, Monoclonal ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - chemistry ; Biological and medical sciences ; Capillary electrophoresis ; Chemical Sciences ; Chromatography ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Drug Compounding ; Drug Delivery Systems ; Drugs ; Electrolytes ; Electrophoresis, Capillary ; Enzyme-Linked Immunosorbent Assay ; Food products ; General pharmacology ; Hardness ; Heparin ; Heparin - administration & dosage ; Heparin - chemistry ; Hydrostatic Pressure ; Influenza ; Insulin ; Insulin - administration & dosage ; Insulin - chemistry ; Life Sciences ; Material chemistry ; Medical sciences ; Methods ; Molecular weight ; Monoclonal antibodies ; Particle Size ; Peptides ; Peptides - chemistry ; Pharmaceutical Preparations ; Pharmaceutical Preparations - chemistry ; Pharmaceutical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmaceuticals ; Pharmacology. Drug treatments ; Solutions ; Surfactants ; Suspensions ; Temperature</subject><ispartof>Pharmaceutical research, 2003-12, Vol.20 (12), p.2036-2040</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Dec 2003</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-4746df0d7c560c0fbe64c628e890f2f3b52b1493fd76e5331783f3106fd0244c3</citedby><orcidid>0000-0002-2661-0478</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15381630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14725371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00170011$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>RIGALDIE, Yohan</creatorcontrib><creatorcontrib>LARGETEAU, Alain</creatorcontrib><creatorcontrib>LEMAGNEN, Gilles</creatorcontrib><creatorcontrib>IBALOT, Fabienne</creatorcontrib><creatorcontrib>PARDON, Patrick</creatorcontrib><creatorcontrib>DEMAZEAU, Gérard</creatorcontrib><creatorcontrib>GRISLAIN, Luc</creatorcontrib><title>Effects of high hydrostatic pressure on several sensitive therapeutic molecules and a soft nanodispersed drug delivery system</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>According to the development in the last decade of industrial processes using high hydrostatic pressure (HHP) for preservation of several commercial food products, novel sterilization or decontamination processes for pharmaceutical products could be conceivable. The aim of this work is to evaluate the effects of HHP on the integrity of insulin and heparin solutions, suspension of monoclonal antibodies and Spherulites.
High performance liquid chromatography, thin layer chromatography, capillary electrophoresis assays, ELISA tests, laser granulometry and spectrophotometry analyses have been performed to compare HHP treated drugs (in a domain of pressure and temperature ranging respectively from 20 up to 500 MPa and from 20 degrees C up to 37 degrees C) vs. untreated ones.
No difference has been detected except for monoclonal antibodies that are altered above 500 MPa.
The structure integrity of sensitive molecule due to the small energy involved by HHP and the development of industrial plants (intended for the decontamination of food products) confer to this technology the potential of a new method for sterilization of fragile drugs and an original alternative to aseptic processes and sterilizing filtration.</description><subject>Antibodies, Monoclonal</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Capillary electrophoresis</subject><subject>Chemical Sciences</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Thin Layer</subject><subject>Drug Compounding</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Electrolytes</subject><subject>Electrophoresis, Capillary</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Food products</subject><subject>General pharmacology</subject><subject>Hardness</subject><subject>Heparin</subject><subject>Heparin - administration & dosage</subject><subject>Heparin - chemistry</subject><subject>Hydrostatic Pressure</subject><subject>Influenza</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - chemistry</subject><subject>Life Sciences</subject><subject>Material chemistry</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Molecular weight</subject><subject>Monoclonal antibodies</subject><subject>Particle Size</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Pharmaceutical Preparations</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical sciences</subject><subject>Pharmaceutical technology. 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The aim of this work is to evaluate the effects of HHP on the integrity of insulin and heparin solutions, suspension of monoclonal antibodies and Spherulites.
High performance liquid chromatography, thin layer chromatography, capillary electrophoresis assays, ELISA tests, laser granulometry and spectrophotometry analyses have been performed to compare HHP treated drugs (in a domain of pressure and temperature ranging respectively from 20 up to 500 MPa and from 20 degrees C up to 37 degrees C) vs. untreated ones.
No difference has been detected except for monoclonal antibodies that are altered above 500 MPa.
The structure integrity of sensitive molecule due to the small energy involved by HHP and the development of industrial plants (intended for the decontamination of food products) confer to this technology the potential of a new method for sterilization of fragile drugs and an original alternative to aseptic processes and sterilizing filtration.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>14725371</pmid><doi>10.1023/B:PHAM.0000008054.80136.5a</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2661-0478</orcidid></addata></record> |
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| ispartof | Pharmaceutical research, 2003-12, Vol.20 (12), p.2036-2040 |
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| subjects | Antibodies, Monoclonal Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Biological and medical sciences Capillary electrophoresis Chemical Sciences Chromatography Chromatography, High Pressure Liquid Chromatography, Thin Layer Drug Compounding Drug Delivery Systems Drugs Electrolytes Electrophoresis, Capillary Enzyme-Linked Immunosorbent Assay Food products General pharmacology Hardness Heparin Heparin - administration & dosage Heparin - chemistry Hydrostatic Pressure Influenza Insulin Insulin - administration & dosage Insulin - chemistry Life Sciences Material chemistry Medical sciences Methods Molecular weight Monoclonal antibodies Particle Size Peptides Peptides - chemistry Pharmaceutical Preparations Pharmaceutical Preparations - chemistry Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology. Drug treatments Solutions Surfactants Suspensions Temperature |
| title | Effects of high hydrostatic pressure on several sensitive therapeutic molecules and a soft nanodispersed drug delivery system |
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