Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents

Several analogues of the 3-substituted-2-oxoindole chemotype were synthesized by condensing isatin or the appropriate haloisatin with some amino acids or histamine under neutral conditions. All the imino derivatives produced were tested for kinase inhibitory properties against three serine/threonine...

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Veröffentlicht in:	European journal of medicinal chemistry 2006-03, Vol.41 (3), p.296-305
Hauptverfasser:	Abadi, Ashraf H., Abou-Seri, Sahar M., Abdel-Rahman, Doaa E., Klein, Christian, Lozach, Olivier, Meijer, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Antineoplastic Agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biochemistry, Molecular Biology Biological and medical sciences Cell Line Cell Proliferation Cell Proliferation - drug effects Drug Screening Assays, Antitumor Endothelial Cells Endothelial Cells - drug effects General aspects Histidine Histidine - analogs & derivatives Histidine - chemical synthesis Histidine - pharmacology Humans Indoles Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Indolinone Inhibitory Concentration 50 Isatin Isatin - analogs & derivatives Isatin - chemistry Kinase inhibitors Life Sciences Medical sciences Models, Molecular Molecular Structure Pharmacology. Drug treatments Protein Kinase Inhibitors Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Umbilical Veins Umbilical Veins - cytology
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