Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp

As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species of Xestospongia collected in Vanuatu was sel...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-07, Vol.14 (13), p.4477-4482
Hauptverfasser:	Laurent, Dominique, Jullian, Valérie, Parenty, Arnaud, Knibiehler, Martine, Dorin, Dominique, Schmitt, Sophie, Lozach, Olivier, Lebouvier, Nicolas, Frostin, Maryvonne, Alby, Frédéric, Maurel, Séverine, Doerig, Christian, Meijer, Laurent, Sauvain, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials Biochemistry, Molecular Biology Biological Assay Chemical Sciences Inhibitory Concentration 50 Life Sciences Medicinal Chemistry Mice Plasmodium falciparum Protein Kinase Inhibitors Quinones Xestospongia
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