Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK

Red wine polyphenols (RWPs) inhibit the expression of vascular endothelial growth factor (VEGF), a major pro-angiogenic and pro-atherosclerotic factor, in vascular smooth muscle cells (VSMCs). The aim of this study was to identify which red wine polyphenols were inhibitory and to determine the mecha...

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Veröffentlicht in:	British journal of pharmacology 2006-10, Vol.149 (3), p.283-290
Hauptverfasser:	Oak, M-H, Bedoui, J E, Madeira, S V F, Chalupsky, K, Schini-Kerth, V B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthocyanins - pharmacology Antioxidants - pharmacology Biochemistry, Molecular Biology Cells, Cultured Cellular Biology Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - physiology Humans JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - physiology Life Sciences MAP Kinase Signaling System - drug effects Molecular biology Muscle, Smooth, Vascular - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Platelet-Derived Growth Factor - antagonists & inhibitors Vascular Endothelial Growth Factor A - secretion
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