Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has remained untested due to the difficulty of selectively generating aneuploidy. Cells and mice with reduced levels of the mitosi...
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| Veröffentlicht in: | Cancer cell 2007, Vol.11 (1), p.25-36 |
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| creator | Weaver, Beth A.A. Silk, Alain D. Montagna, Cristina Verdier-Pinard, Pascal Cleveland, Don W. |
| description | An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has remained untested due to the difficulty of selectively generating aneuploidy. Cells and mice with reduced levels of the mitosis-specific, centromere-linked motor protein CENP-E are now shown to develop aneuploidy and chromosomal instability in vitro and in vivo. An increased rate of aneuploidy does drive an elevated level of spontaneous lymphomas and lung tumors in aged animals. Remarkably, however, in examples of chemically or genetically induced tumor formation, an increased rate of aneuploidy is a more effective inhibitor than initiator of tumorigenesis. These findings reveal a role of aneuploidy and chromosomal instability in preventing tumorigenesis. |
| doi_str_mv | 10.1016/j.ccr.2006.12.003 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aneuploidy Animals Cancer Cell Transformation, Neoplastic - genetics CELLCYCLE Cells, Cultured Cellular Biology Chromosomal Proteins, Non-Histone - metabolism Embryo, Mammalian Fibroblasts - pathology Fibroblasts - physiology In Situ Hybridization, Fluorescence Life Sciences Mice Neoplasms - genetics |
| title | Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor |
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