Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models
Since the discovery of adult neural stem cells, mobilization of endogenous stem cells from the subventricular zone (SVZ) emerges as a promising strategy to promote brain repair. Here, we examined the effect of environment enrichment on SVZ cell mobilization in demyelinating pathologies. We showed th...
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| Veröffentlicht in: | The European journal of neuroscience 2007-02, Vol.25 (3), p.761-771 |
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| creator | Magalon, Karine Cantarella, Cristina Monti, Gilberte Cayre, Myriam Durbec, Pascale |
| description | Since the discovery of adult neural stem cells, mobilization of endogenous stem cells from the subventricular zone (SVZ) emerges as a promising strategy to promote brain repair. Here, we examined the effect of environment enrichment on SVZ cell mobilization in demyelinating pathologies. We showed that enriched housing conditions reduced functional impairment in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis. Furthermore, both in a focal demyelination model (lysolecithine injection) and in the inflammatory EAE model, SVZ mitotic activity and the number of SVZ‐derived cells in demyelinated areas were significantly increased by environment enrichment. Enriched housing conditions also promoted the oligodendrocyte fate of SVZ‐recruited cells in the EAE lesions. Altogether our results show that environment enrichment provides beneficial conditions to promote the mobilization of neural progenitors into demyelinating lesions and to favour functional recovery. |
| doi_str_mv | 10.1111/j.1460-9568.2007.05335.x |
| format | Article |
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Here, we examined the effect of environment enrichment on SVZ cell mobilization in demyelinating pathologies. We showed that enriched housing conditions reduced functional impairment in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis. Furthermore, both in a focal demyelination model (lysolecithine injection) and in the inflammatory EAE model, SVZ mitotic activity and the number of SVZ‐derived cells in demyelinated areas were significantly increased by environment enrichment. Enriched housing conditions also promoted the oligodendrocyte fate of SVZ‐recruited cells in the EAE lesions. Altogether our results show that environment enrichment provides beneficial conditions to promote the mobilization of neural progenitors into demyelinating lesions and to favour functional recovery.</description><subject>Animals</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Division - physiology</subject><subject>Cellular Biology</subject><subject>Disease Models, Animal</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - physiopathology</subject><subject>Environment Design</subject><subject>environment enrichment</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motor Activity - physiology</subject><subject>Multiple Sclerosis - pathology</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>myelin</subject><subject>neural stem cells</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>proliferation</subject><subject>Recovery of Function - physiology</subject><subject>recruitment</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - physiology</subject><subject>subventricular zone</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGP1CAUxonRuOPqv2B6MvHQCmWgcPCw2Yw7mslqVo3eCAOvLiOlK7TrjH-91E7Go3KB9_H7Hrx8CBUEVySvV7uKLDkuJeOiqjFuKswoZdX-AVqcLh6iBZaMloLwr2foSUo7jLHgS_YYnZGmloJjvECwCtGZW7AFhHsX-9BBGIq72Hf9AKnQdvRDEWCM2k_qNwhu6GNhwPui67fOu196cH0oXMj1mKCw0B3AuzDLXW_Bp6foUat9gmfH_Rx9frP6dLkuN--v3l5ebErDKGelXFJBmCEMSyubJZWCWWhb3hpt7da02vBaamMIhlYQzXGumoZDbbc1NiDpOXo5973VXt1F1-l4UL12an2xUZOGMWGS1fSeZPbFzOaxfoyQBtW5NM2lA-RBFJeY8qWo_wnWODckXGRQzKCJfUoR2tMXCFZTbmqnpnjUFI-aclN_clP7bH1-fGPcdmD_Go9BZeD1DPx0Hg7_3Vit3l1Pp-wvZ79LA-xPfh2_K97Qhqkv11fqg6Q3H9f0Rkn6G6u6t5U</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Magalon, Karine</creator><creator>Cantarella, Cristina</creator><creator>Monti, Gilberte</creator><creator>Cayre, Myriam</creator><creator>Durbec, Pascale</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8590-4425</orcidid></search><sort><creationdate>200702</creationdate><title>Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models</title><author>Magalon, Karine ; Cantarella, Cristina ; Monti, Gilberte ; Cayre, Myriam ; Durbec, Pascale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5365-943815c1509d9743985deff6fcaddbcfac629acc10ef81a6029a776e2db20ce93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Division - physiology</topic><topic>Cellular Biology</topic><topic>Disease Models, Animal</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - physiopathology</topic><topic>Environment Design</topic><topic>environment enrichment</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity - physiology</topic><topic>Multiple Sclerosis - pathology</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>myelin</topic><topic>neural stem cells</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>proliferation</topic><topic>Recovery of Function - physiology</topic><topic>recruitment</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - physiology</topic><topic>subventricular zone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magalon, Karine</creatorcontrib><creatorcontrib>Cantarella, Cristina</creatorcontrib><creatorcontrib>Monti, Gilberte</creatorcontrib><creatorcontrib>Cayre, Myriam</creatorcontrib><creatorcontrib>Durbec, Pascale</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magalon, Karine</au><au>Cantarella, Cristina</au><au>Monti, Gilberte</au><au>Cayre, Myriam</au><au>Durbec, Pascale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2007-02</date><risdate>2007</risdate><volume>25</volume><issue>3</issue><spage>761</spage><epage>771</epage><pages>761-771</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Since the discovery of adult neural stem cells, mobilization of endogenous stem cells from the subventricular zone (SVZ) emerges as a promising strategy to promote brain repair. Here, we examined the effect of environment enrichment on SVZ cell mobilization in demyelinating pathologies. We showed that enriched housing conditions reduced functional impairment in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis. Furthermore, both in a focal demyelination model (lysolecithine injection) and in the inflammatory EAE model, SVZ mitotic activity and the number of SVZ‐derived cells in demyelinated areas were significantly increased by environment enrichment. Enriched housing conditions also promoted the oligodendrocyte fate of SVZ‐recruited cells in the EAE lesions. 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| subjects | Animals Cell Differentiation - physiology Cell Division - physiology Cellular Biology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - physiopathology Environment Design environment enrichment Life Sciences Mice Mice, Inbred C57BL Motor Activity - physiology Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology myelin neural stem cells Neurons - cytology Neurons - physiology Physical Conditioning, Animal - physiology proliferation Recovery of Function - physiology recruitment Stem Cells - cytology Stem Cells - physiology subventricular zone |
| title | Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models |
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