Hydrogen/Deuterium Exchange Mass Spectrometric Analysis of Conformational Changes Accompanying the Assembly of the Yeast Prion Ure2p into Protein Fibrils

The Ure2 protein from baker's yeast ( Saccharomyces cerevisiae) has prion properties. In vitro, at neutral pH, soluble Ure2p forms long, twisted fibrils. Two models have been proposed to account for Ure2p polymerization. The first postulates that a segment of 70 amino acid residues in the flexi...

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Veröffentlicht in:Journal of molecular biology 2007-06, Vol.369 (4), p.1113-1125
Hauptverfasser: Redeker, Virginie, Halgand, Frédéric, Le Caer, Jean-Pierre, Bousset, Luc, Laprévote, Olivier, Melki, Ronald
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Sprache:eng
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