In vitro and in vivo corrosion measurements of magnesium alloys
The in vivo corrosion of magnesium alloys might provide a new mechanism which would allow degradable metal implants to be applied in musculo-skeletal surgery. This would particularly be true if magnesium alloys with controlled in vivo corrosion rates could be developed. Since the magnesium corrosion...
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| Veröffentlicht in: | Biomaterials 2006-03, Vol.27 (7), p.1013-1018 |
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| creator | Witte, Frank Fischer, Jens Nellesen, Jens Crostack, Horst-Artur Kaese, Volker Pisch, Alexander Beckmann, Felix Windhagen, Henning |
| description | The in vivo corrosion of magnesium alloys might provide a new mechanism which would allow degradable metal implants to be applied in musculo-skeletal surgery. This would particularly be true if magnesium alloys with controlled in vivo corrosion rates could be developed. Since the magnesium corrosion process depends on its corrosive environment, the corrosion rates of magnesium alloys under standard in vitro environmental conditions were compared to corrosion rates in an in vivo animal model. Two gravity-cast magnesium alloys (AZ91D, LAE442) were used in these investigations. Standardized immersion and electrochemical tests according to ASTM norms were performed. The in vivo corrosion tests were carried out by intramedullar implantation of sample rods of the magnesium alloys in guinea pig femura. The reduction in implant volume was determined by synchrotron-radiation-based microtomography. We found that in vivo corrosion was about four orders of magnitude lower than in vitro corrosion of the tested alloys. Furthermore, the tendency of the corrosion rates obtained from in vitro corrosion tests were in the opposite direction as those obtained from the in vivo study. The results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys. |
| doi_str_mv | 10.1016/j.biomaterials.2005.07.037 |
| format | Article |
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This would particularly be true if magnesium alloys with controlled in vivo corrosion rates could be developed. Since the magnesium corrosion process depends on its corrosive environment, the corrosion rates of magnesium alloys under standard in vitro environmental conditions were compared to corrosion rates in an in vivo animal model. Two gravity-cast magnesium alloys (AZ91D, LAE442) were used in these investigations. Standardized immersion and electrochemical tests according to ASTM norms were performed. The in vivo corrosion tests were carried out by intramedullar implantation of sample rods of the magnesium alloys in guinea pig femura. The reduction in implant volume was determined by synchrotron-radiation-based microtomography. We found that in vivo corrosion was about four orders of magnitude lower than in vitro corrosion of the tested alloys. Furthermore, the tendency of the corrosion rates obtained from in vitro corrosion tests were in the opposite direction as those obtained from the in vivo study. The results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2005.07.037</identifier><identifier>PMID: 16122786</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Absorbable Implants ; Alloys - analysis ; Alloys - chemistry ; Animals ; Biocompatible Materials - chemistry ; Biodegradation ; Body Fluids - chemistry ; Bone ; Chemical and Process Engineering ; Chemical Sciences ; Corrosion ; Engineering Sciences ; Femur - pathology ; Femur - surgery ; Guinea Pigs ; Implant ; Magnesium ; Magnesium - analysis ; Magnesium - chemistry ; Material chemistry ; Materials Testing ; Surface Properties</subject><ispartof>Biomaterials, 2006-03, Vol.27 (7), p.1013-1018</ispartof><rights>2005 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a713100685cec6b3717c05dbb8c43c0b3222601f5b836ca2d005e09c55ff7c3c3</citedby><cites>FETCH-LOGICAL-c540t-a713100685cec6b3717c05dbb8c43c0b3222601f5b836ca2d005e09c55ff7c3c3</cites><orcidid>0000-0003-3451-5224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2005.07.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16122786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00141078$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Witte, Frank</creatorcontrib><creatorcontrib>Fischer, Jens</creatorcontrib><creatorcontrib>Nellesen, Jens</creatorcontrib><creatorcontrib>Crostack, Horst-Artur</creatorcontrib><creatorcontrib>Kaese, Volker</creatorcontrib><creatorcontrib>Pisch, Alexander</creatorcontrib><creatorcontrib>Beckmann, Felix</creatorcontrib><creatorcontrib>Windhagen, Henning</creatorcontrib><title>In vitro and in vivo corrosion measurements of magnesium alloys</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The in vivo corrosion of magnesium alloys might provide a new mechanism which would allow degradable metal implants to be applied in musculo-skeletal surgery. This would particularly be true if magnesium alloys with controlled in vivo corrosion rates could be developed. Since the magnesium corrosion process depends on its corrosive environment, the corrosion rates of magnesium alloys under standard in vitro environmental conditions were compared to corrosion rates in an in vivo animal model. Two gravity-cast magnesium alloys (AZ91D, LAE442) were used in these investigations. Standardized immersion and electrochemical tests according to ASTM norms were performed. The in vivo corrosion tests were carried out by intramedullar implantation of sample rods of the magnesium alloys in guinea pig femura. The reduction in implant volume was determined by synchrotron-radiation-based microtomography. We found that in vivo corrosion was about four orders of magnitude lower than in vitro corrosion of the tested alloys. Furthermore, the tendency of the corrosion rates obtained from in vitro corrosion tests were in the opposite direction as those obtained from the in vivo study. The results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys.</description><subject>Absorbable Implants</subject><subject>Alloys - analysis</subject><subject>Alloys - chemistry</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biodegradation</subject><subject>Body Fluids - chemistry</subject><subject>Bone</subject><subject>Chemical and Process Engineering</subject><subject>Chemical Sciences</subject><subject>Corrosion</subject><subject>Engineering Sciences</subject><subject>Femur - pathology</subject><subject>Femur - surgery</subject><subject>Guinea Pigs</subject><subject>Implant</subject><subject>Magnesium</subject><subject>Magnesium - analysis</subject><subject>Magnesium - chemistry</subject><subject>Material chemistry</subject><subject>Materials Testing</subject><subject>Surface Properties</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhK6CIAxKHhBk7thMuqCp_WmklLnC2HGcCXiVxsZOV-u3raFfArZysGf3GM-89xt4gVAio3h-qzofJLhS9HVPFAWQFugKhn7AdNropZQvyKdsB1rxsFfIL9iKlA-Qaav6cXWDucd2oHft4OxdHv8RQ2Lkv_FYcQ-FCjCH5MBcT2bRGmmheUhGGYrI_Z0p-nQo7juE-vWTPhnwEvTq_l-zHl8_fr2_K_bevt9dX-9LJGpbSahQIoBrpyKlOaNQOZN91jauFg05wzhXgILtGKGd5nzURtE7KYdBOOHHJ3p3-_WVHcxf9ZOO9Cdabm6u92XqbOATdHDGzb0_sXQy_V0qLmXxyNI52prAmoyGbpOTjIG9RKRTwKIhtLTcJGfxwAl32L0Ua_tyKYLbwzMH8G57ZwjOgTQ4vD78-b1m7ifq_o-e0MvDpBFB2-ugpmuQ8zY56H8ktpg_-f_Y8AEtJsCA</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Witte, Frank</creator><creator>Fischer, Jens</creator><creator>Nellesen, Jens</creator><creator>Crostack, Horst-Artur</creator><creator>Kaese, Volker</creator><creator>Pisch, Alexander</creator><creator>Beckmann, Felix</creator><creator>Windhagen, Henning</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SE</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-3451-5224</orcidid></search><sort><creationdate>200603</creationdate><title>In vitro and in vivo corrosion measurements of magnesium alloys</title><author>Witte, Frank ; Fischer, Jens ; Nellesen, Jens ; Crostack, Horst-Artur ; Kaese, Volker ; Pisch, Alexander ; Beckmann, Felix ; Windhagen, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a713100685cec6b3717c05dbb8c43c0b3222601f5b836ca2d005e09c55ff7c3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorbable Implants</topic><topic>Alloys - analysis</topic><topic>Alloys - chemistry</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biodegradation</topic><topic>Body Fluids - chemistry</topic><topic>Bone</topic><topic>Chemical and Process Engineering</topic><topic>Chemical Sciences</topic><topic>Corrosion</topic><topic>Engineering Sciences</topic><topic>Femur - pathology</topic><topic>Femur - surgery</topic><topic>Guinea Pigs</topic><topic>Implant</topic><topic>Magnesium</topic><topic>Magnesium - analysis</topic><topic>Magnesium - chemistry</topic><topic>Material chemistry</topic><topic>Materials Testing</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Witte, Frank</creatorcontrib><creatorcontrib>Fischer, Jens</creatorcontrib><creatorcontrib>Nellesen, Jens</creatorcontrib><creatorcontrib>Crostack, Horst-Artur</creatorcontrib><creatorcontrib>Kaese, Volker</creatorcontrib><creatorcontrib>Pisch, Alexander</creatorcontrib><creatorcontrib>Beckmann, Felix</creatorcontrib><creatorcontrib>Windhagen, Henning</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Witte, Frank</au><au>Fischer, Jens</au><au>Nellesen, Jens</au><au>Crostack, Horst-Artur</au><au>Kaese, Volker</au><au>Pisch, Alexander</au><au>Beckmann, Felix</au><au>Windhagen, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo corrosion measurements of magnesium alloys</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2006-03</date><risdate>2006</risdate><volume>27</volume><issue>7</issue><spage>1013</spage><epage>1018</epage><pages>1013-1018</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The in vivo corrosion of magnesium alloys might provide a new mechanism which would allow degradable metal implants to be applied in musculo-skeletal surgery. This would particularly be true if magnesium alloys with controlled in vivo corrosion rates could be developed. Since the magnesium corrosion process depends on its corrosive environment, the corrosion rates of magnesium alloys under standard in vitro environmental conditions were compared to corrosion rates in an in vivo animal model. Two gravity-cast magnesium alloys (AZ91D, LAE442) were used in these investigations. Standardized immersion and electrochemical tests according to ASTM norms were performed. The in vivo corrosion tests were carried out by intramedullar implantation of sample rods of the magnesium alloys in guinea pig femura. The reduction in implant volume was determined by synchrotron-radiation-based microtomography. We found that in vivo corrosion was about four orders of magnitude lower than in vitro corrosion of the tested alloys. Furthermore, the tendency of the corrosion rates obtained from in vitro corrosion tests were in the opposite direction as those obtained from the in vivo study. The results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16122786</pmid><doi>10.1016/j.biomaterials.2005.07.037</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3451-5224</orcidid></addata></record> |
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| subjects | Absorbable Implants Alloys - analysis Alloys - chemistry Animals Biocompatible Materials - chemistry Biodegradation Body Fluids - chemistry Bone Chemical and Process Engineering Chemical Sciences Corrosion Engineering Sciences Femur - pathology Femur - surgery Guinea Pigs Implant Magnesium Magnesium - analysis Magnesium - chemistry Material chemistry Materials Testing Surface Properties |
| title | In vitro and in vivo corrosion measurements of magnesium alloys |
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