A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity

The Toll receptor was originally identified as an indispensable molecule for Drosophila embryonic development and subsequently as an essential component of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro-Spätzle protein to generate the Toll ligand...

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Veröffentlicht in:	Developmental cell 2006, Vol.10 (1), p.45-55
Hauptverfasser:	Jang, In-Hwan, Chosa, Naoyuki, Kim, Sung-Hee, Nam, Hyuck-Jin, Lemaitre, Bruno, Ochiai, Masanori, Kambris, Zakaria, Brun, Sylvain, Hashimoto, Carl, Ashida, Masaaki, Brey, Paul T., Lee, Won-Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biochemistry, Molecular Biology Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Drosophila Drosophila - immunology Drosophila Proteins Drosophila Proteins - deficiency Drosophila Proteins - metabolism Embryo, Nonmammalian Embryo, Nonmammalian - metabolism Embryonic Induction Enzyme Activation Fat Body Fat Body - immunology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Immunity Immunity - physiology Immunology Innate immunity Life Sciences Models, Biological Molecular and cellular biology Molecular Sequence Data MOLIMMUNO Protein Binding Protein Binding - physiology Protein Structure, Secondary Recombinant Proteins Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger RNA, Messenger - biosynthesis Sequence Homology, Amino Acid Serine Endopeptidases Serine Endopeptidases - physiology Signal Transduction Signal Transduction - physiology Time Factors Toll-Like Receptors Toll-Like Receptors - metabolism
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