Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity

CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26−/− mice resulting from targeted inactivation of the gene. These an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Behavioural brain research 2006-08, Vol.171 (2), p.279-285
Hauptverfasser:	El Yacoubi, Malika, Vaugeois, Jean-Marie, Marguet, Didier, Sauze, Nicole, Guieu, Régis, Costentin, Jean, Fenouillet, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Affectivity. Emotion Analysis of Variance Animals Anxiety Anxiety - enzymology Behavior, Animal - physiology Biological and medical sciences Depression - enzymology Dipeptidyl Peptidase 4 - genetics Dipeptidyl Peptidase 4 - metabolism Dipeptidyl Peptidase 4 - physiology DPPIV/CD26 Exploratory Behavior - physiology Forced swim test Fundamental and applied biological sciences. Psychology Gene targeted inactivation Immobility Response, Tonic - physiology Life Sciences Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Motor activity Motor Activity - physiology Neurons and Cognition Neuropharmacology Personality. Affectivity Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Tail suspension test
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!