Ciboulot Regulates Actin Assembly during Drosophila Brain Metamorphosis
A dynamic actin cytoskeleton is essential for the remodeling of cell shape during development, but the specific roles of many actin partners remain unclear. Here we characterize a novel actin binding protein, Ciboulot (Cib), which plays a major role in axonal growth during Drosophila brain metamorph...
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| Veröffentlicht in: | Cell 2000-09, Vol.102 (6), p.797-808 |
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| creator | Boquet, Isabelle Boujemaa, Rajaa Carlier, Marie-France Préat, Thomas |
| description | A dynamic actin cytoskeleton is essential for the remodeling of cell shape during development, but the specific roles of many actin partners remain unclear. Here we characterize a novel actin binding protein, Ciboulot (Cib), which plays a major role in axonal growth during
Drosophila brain metamorphosis. Loss of Cib function leads to axonal growth defects in the central brain, while overexpression of the gene during development leads to overgrown projections. The Cib protein displays strong sequence similarity to β-thymosins but has biochemical properties like profilin: the Cib-actin complex participates in actin filament assembly exclusively at the barbed end, and Cib enhances actin-based motility in vitro. Genetic experiments show that Cib and the
Drosophila profilin protein Chickadee (Chic) cooperate in central brain metamorphosis. |
| doi_str_mv | 10.1016/S0092-8674(00)00068-4 |
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Drosophila brain metamorphosis. Loss of Cib function leads to axonal growth defects in the central brain, while overexpression of the gene during development leads to overgrown projections. The Cib protein displays strong sequence similarity to β-thymosins but has biochemical properties like profilin: the Cib-actin complex participates in actin filament assembly exclusively at the barbed end, and Cib enhances actin-based motility in vitro. Genetic experiments show that Cib and the
Drosophila profilin protein Chickadee (Chic) cooperate in central brain metamorphosis.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)00068-4</identifier><identifier>PMID: 11030623</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>actin ; Actins ; Actins - metabolism ; Animals ; Brain ; Brain - cytology ; Brain - embryology ; Brain - metabolism ; Cell Differentiation ; Cell Differentiation - physiology ; Cell Size ; Cell Size - physiology ; Contractile Proteins ; Drosophila ; Drosophila - embryology ; Drosophila melanogaster ; Drosophila Proteins ; Gene Expression Regulation, Developmental ; Life Sciences ; Listeria monocytogenes ; Listeria monocytogenes - metabolism ; Metamorphosis, Biological ; Metamorphosis, Biological - physiology ; Microfilament Proteins ; Microfilament Proteins - genetics ; Microfilament Proteins - metabolism ; Molecular Sequence Data ; Movement ; Mutagenesis ; Mutagenesis - physiology ; Nerve Tissue Proteins ; Neurons ; Neurons - physiology ; Neurons and Cognition ; Profilins ; Repetitive Sequences, Nucleic Acid ; Sequence Homology, Amino Acid ; Thymosin ; Thymosin - genetics</subject><ispartof>Cell, 2000-09, Vol.102 (6), p.797-808</ispartof><rights>2000 Cell Press</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-83fa3889651191e404fe3f32e8fc922cbcb3337bd03feeabca88db38e21b1b683</citedby><cites>FETCH-LOGICAL-c591t-83fa3889651191e404fe3f32e8fc922cbcb3337bd03feeabca88db38e21b1b683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867400000684$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11030623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00122176$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boquet, Isabelle</creatorcontrib><creatorcontrib>Boujemaa, Rajaa</creatorcontrib><creatorcontrib>Carlier, Marie-France</creatorcontrib><creatorcontrib>Préat, Thomas</creatorcontrib><title>Ciboulot Regulates Actin Assembly during Drosophila Brain Metamorphosis</title><title>Cell</title><addtitle>Cell</addtitle><description>A dynamic actin cytoskeleton is essential for the remodeling of cell shape during development, but the specific roles of many actin partners remain unclear. Here we characterize a novel actin binding protein, Ciboulot (Cib), which plays a major role in axonal growth during
Drosophila brain metamorphosis. Loss of Cib function leads to axonal growth defects in the central brain, while overexpression of the gene during development leads to overgrown projections. The Cib protein displays strong sequence similarity to β-thymosins but has biochemical properties like profilin: the Cib-actin complex participates in actin filament assembly exclusively at the barbed end, and Cib enhances actin-based motility in vitro. Genetic experiments show that Cib and the
Drosophila profilin protein Chickadee (Chic) cooperate in central brain metamorphosis.</description><subject>actin</subject><subject>Actins</subject><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Brain - embryology</subject><subject>Brain - metabolism</subject><subject>Cell Differentiation</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Size</subject><subject>Cell Size - physiology</subject><subject>Contractile Proteins</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila melanogaster</subject><subject>Drosophila Proteins</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Life Sciences</subject><subject>Listeria monocytogenes</subject><subject>Listeria monocytogenes - metabolism</subject><subject>Metamorphosis, Biological</subject><subject>Metamorphosis, Biological - physiology</subject><subject>Microfilament Proteins</subject><subject>Microfilament Proteins - genetics</subject><subject>Microfilament Proteins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Movement</subject><subject>Mutagenesis</subject><subject>Mutagenesis - physiology</subject><subject>Nerve Tissue Proteins</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neurons and Cognition</subject><subject>Profilins</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Sequence Homology, Amino Acid</subject><subject>Thymosin</subject><subject>Thymosin - genetics</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaTYfPyHBp5Ic3M5I_pBPZbv5KmwppM1ZSPI4q2KvtpIdyL-PNrskx5wGhuedl3kYO0X4ioDVtz8ADc9lVRfnABcAUMm8-MBmCE2dF1jzj2z2ihywwxj_JUiWZfmZHSCCgIqLGbtZOOOn3o_ZHT1MvR4pZnM7unU2j5EG0z9l7RTc-iG7DD76zcr1OvsRdAJ-0agHHzYrH108Zp863Uc62c8jdn999Xdxmy9_3_xczJe5LRsccyk6LaRsqhKxQSqg6Eh0gpPsbMO5NdYIIWrTguiItLFaytYISRwNmkqKI3axu7vSvdoEN-jwpLx26na-VNsdAHKOdfWIif2yYzfB_58ojmpw0VLf6zX5KapEFVA3ZQLLHWjTjzFQ93oZQW1tqxfbaqsyFagX26pIubN9wWQGat9Se70J-L4DKCl5dBRUtI7WlloXyI6q9e6dimdThY5M</recordid><startdate>20000915</startdate><enddate>20000915</enddate><creator>Boquet, Isabelle</creator><creator>Boujemaa, Rajaa</creator><creator>Carlier, Marie-France</creator><creator>Préat, Thomas</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>1XC</scope></search><sort><creationdate>20000915</creationdate><title>Ciboulot Regulates Actin Assembly during Drosophila Brain Metamorphosis</title><author>Boquet, Isabelle ; Boujemaa, Rajaa ; Carlier, Marie-France ; Préat, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-83fa3889651191e404fe3f32e8fc922cbcb3337bd03feeabca88db38e21b1b683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>actin</topic><topic>Actins</topic><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Brain</topic><topic>Brain - cytology</topic><topic>Brain - embryology</topic><topic>Brain - metabolism</topic><topic>Cell Differentiation</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Size</topic><topic>Cell Size - physiology</topic><topic>Contractile Proteins</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila melanogaster</topic><topic>Drosophila Proteins</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Life Sciences</topic><topic>Listeria monocytogenes</topic><topic>Listeria monocytogenes - metabolism</topic><topic>Metamorphosis, Biological</topic><topic>Metamorphosis, Biological - physiology</topic><topic>Microfilament Proteins</topic><topic>Microfilament Proteins - genetics</topic><topic>Microfilament Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Movement</topic><topic>Mutagenesis</topic><topic>Mutagenesis - physiology</topic><topic>Nerve Tissue Proteins</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neurons and Cognition</topic><topic>Profilins</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Sequence Homology, Amino Acid</topic><topic>Thymosin</topic><topic>Thymosin - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boquet, Isabelle</creatorcontrib><creatorcontrib>Boujemaa, Rajaa</creatorcontrib><creatorcontrib>Carlier, Marie-France</creatorcontrib><creatorcontrib>Préat, Thomas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boquet, Isabelle</au><au>Boujemaa, Rajaa</au><au>Carlier, Marie-France</au><au>Préat, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ciboulot Regulates Actin Assembly during Drosophila Brain Metamorphosis</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2000-09-15</date><risdate>2000</risdate><volume>102</volume><issue>6</issue><spage>797</spage><epage>808</epage><pages>797-808</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>A dynamic actin cytoskeleton is essential for the remodeling of cell shape during development, but the specific roles of many actin partners remain unclear. Here we characterize a novel actin binding protein, Ciboulot (Cib), which plays a major role in axonal growth during
Drosophila brain metamorphosis. Loss of Cib function leads to axonal growth defects in the central brain, while overexpression of the gene during development leads to overgrown projections. The Cib protein displays strong sequence similarity to β-thymosins but has biochemical properties like profilin: the Cib-actin complex participates in actin filament assembly exclusively at the barbed end, and Cib enhances actin-based motility in vitro. Genetic experiments show that Cib and the
Drosophila profilin protein Chickadee (Chic) cooperate in central brain metamorphosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11030623</pmid><doi>10.1016/S0092-8674(00)00068-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | actin Actins Actins - metabolism Animals Brain Brain - cytology Brain - embryology Brain - metabolism Cell Differentiation Cell Differentiation - physiology Cell Size Cell Size - physiology Contractile Proteins Drosophila Drosophila - embryology Drosophila melanogaster Drosophila Proteins Gene Expression Regulation, Developmental Life Sciences Listeria monocytogenes Listeria monocytogenes - metabolism Metamorphosis, Biological Metamorphosis, Biological - physiology Microfilament Proteins Microfilament Proteins - genetics Microfilament Proteins - metabolism Molecular Sequence Data Movement Mutagenesis Mutagenesis - physiology Nerve Tissue Proteins Neurons Neurons - physiology Neurons and Cognition Profilins Repetitive Sequences, Nucleic Acid Sequence Homology, Amino Acid Thymosin Thymosin - genetics |
| title | Ciboulot Regulates Actin Assembly during Drosophila Brain Metamorphosis |
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