Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention

The present experiment was designed to study changes in behavior following immunolesioning of the basal forebrain cholinergic system. Rats were lesioned at 3 months of age by injection of the 192 IgG-saporin immunotoxin into the medial septum area and the nucleus basalis magnocellularis, and then te...

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Veröffentlicht in:	Neuroscience 2005, Vol.132 (1), p.13-32
Hauptverfasser:	Paban, V., Jaffard, M., Chambon, C., Malafosse, M., Alescio-Lautier, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	192 IgG-saporin Acetylcholine - metabolism Animals Antibodies, Monoclonal Basal Nucleus of Meynert - pathology Basal Nucleus of Meynert - physiopathology Behavior, Animal - physiology Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cholinergic Fibers - metabolism Cholinergic Fibers - pathology Denervation Disease Models, Animal Environment Design Immunotoxins Life Sciences Male Maze Learning - physiology memory Memory Disorders - pathology Memory Disorders - physiopathology Memory Disorders - therapy N-Glycosyl Hydrolases Neuronal Plasticity - physiology Neurons and Cognition Neurotoxins nonmatching-to-position object-location object-recognition Physical Stimulation Rats Rats, Wistar Recognition (Psychology) - physiology Ribosome Inactivating Proteins, Type 1 Septal Nuclei - pathology Septal Nuclei - physiopathology Time Factors
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