Multidrug resistance reversal agent from Jatropha elliptica
Bioassay-guided fractionation of Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester ( 8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of Staphylococcus aureus. As part of an ongoing project to iden...
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| Veröffentlicht in: | Phytochemistry (Oxford) 2005-08, Vol.66 (15), p.1804-1811 |
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| container_title | Phytochemistry (Oxford) |
| container_volume | 66 |
| creator | Marquez, Béatrice Neuville, Luc Moreau, Nicole J. Genet, Jean-Pierre dos Santos, Aldenir Feitosa Caño de Andrade, Maria Cristina Goulart Sant’Ana, Antônio Euzébio |
| description | Bioassay-guided fractionation of
Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of
Staphylococcus aureus.
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of
Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of
Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (
8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration. |
| doi_str_mv | 10.1016/j.phytochem.2005.06.008 |
| format | Article |
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Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of
Staphylococcus aureus.
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of
Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of
Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (
8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2005.06.008</identifier><identifier>PMID: 16051285</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester ; Anti-Bacterial Agents - pharmacology ; antibacterial properties ; Antifungal Agents - pharmacology ; Biological and medical sciences ; Biological Factors ; Chemical constitution ; chemical structure ; Drug Resistance, Multiple - drug effects ; Efflux pump inhibitor ; Fluoroquinolone ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Jatropha ; Jatropha elliptica ; Kinetics ; Medical sciences ; medicinal plants ; Microbial Sensitivity Tests ; multiple drug resistance ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; plant extracts ; Plant Extracts - pharmacology ; Plant physiology and development ; pyridines ; Resistance ; spectral analysis ; Staphylococcus aureus</subject><ispartof>Phytochemistry (Oxford), 2005-08, Vol.66 (15), p.1804-1811</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-c45b88b4fe5659597776b1f988e903045eca8c4629f57bdb2cd7a2a3bce3fb813</citedby><cites>FETCH-LOGICAL-c488t-c45b88b4fe5659597776b1f988e903045eca8c4629f57bdb2cd7a2a3bce3fb813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031942205002864$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17016482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16051285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00091888$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Marquez, Béatrice</creatorcontrib><creatorcontrib>Neuville, Luc</creatorcontrib><creatorcontrib>Moreau, Nicole J.</creatorcontrib><creatorcontrib>Genet, Jean-Pierre</creatorcontrib><creatorcontrib>dos Santos, Aldenir Feitosa</creatorcontrib><creatorcontrib>Caño de Andrade, Maria Cristina</creatorcontrib><creatorcontrib>Goulart Sant’Ana, Antônio Euzébio</creatorcontrib><title>Multidrug resistance reversal agent from Jatropha elliptica</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Bioassay-guided fractionation of
Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of
Staphylococcus aureus.
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of
Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of
Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (
8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration.</description><subject>2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibacterial properties</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological Factors</subject><subject>Chemical constitution</subject><subject>chemical structure</subject><subject>Drug Resistance, Multiple - drug effects</subject><subject>Efflux pump inhibitor</subject><subject>Fluoroquinolone</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Jatropha</subject><subject>Jatropha elliptica</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Microbial Sensitivity Tests</subject><subject>multiple drug resistance</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant physiology and development</subject><subject>pyridines</subject><subject>Resistance</subject><subject>spectral analysis</subject><subject>Staphylococcus aureus</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9v0zAYBnALgVgZfAWWC0gcGl47_vNanKoJGKiIA-xsOY7TukqaYCeV9u1xlWo77hJH0c_O4_ch5IZCSYHKz4dy3D9Mg9v7vmQAogRZAuALsqKoqnWlAF6SFUBF15ozdkXepHSADIWUr8kVlSAoQ7EiX37N3RSaOO-K6FNIkz06n19PPibbFXbnj1PRxqEvftopDuPeFr7rwjgFZ9-SV63tkn93Wa_J_bevf2_v1tvf33_cbrZrxxGn_BQ1Ys1bL6TQQiulZE1bjeg1VMCFdxYdl0y3QtVNzVyjLLNV7XzV1kira_JpOXdvOzPG0Nv4YAYbzN1ma87f8sU0RcTT2X5c7BiHf7NPk-lDcjmyPfphTkYi58gZfxayPGZKtc5QLdDFIaXo28cIFMy5DHMwj2WYcxkGZI6Eeef7yy_muvfN077L9DP4cAE2Odu1MQ8_pCen8ukcWXY3i2vtYOwuZnP_JwesgAJjCCqLzSJ87uEUfDTJBZ-rbEL0bjLNEJ6N-x-OY7Ro</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Marquez, Béatrice</creator><creator>Neuville, Luc</creator><creator>Moreau, Nicole J.</creator><creator>Genet, Jean-Pierre</creator><creator>dos Santos, Aldenir Feitosa</creator><creator>Caño de Andrade, Maria Cristina</creator><creator>Goulart Sant’Ana, Antônio Euzébio</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20050801</creationdate><title>Multidrug resistance reversal agent from Jatropha elliptica</title><author>Marquez, Béatrice ; Neuville, Luc ; Moreau, Nicole J. ; Genet, Jean-Pierre ; dos Santos, Aldenir Feitosa ; Caño de Andrade, Maria Cristina ; Goulart Sant’Ana, Antônio Euzébio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-c45b88b4fe5659597776b1f988e903045eca8c4629f57bdb2cd7a2a3bce3fb813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibacterial properties</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological Factors</topic><topic>Chemical constitution</topic><topic>chemical structure</topic><topic>Drug Resistance, Multiple - drug effects</topic><topic>Efflux pump inhibitor</topic><topic>Fluoroquinolone</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Jatropha</topic><topic>Jatropha elliptica</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Microbial Sensitivity Tests</topic><topic>multiple drug resistance</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant physiology and development</topic><topic>pyridines</topic><topic>Resistance</topic><topic>spectral analysis</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marquez, Béatrice</creatorcontrib><creatorcontrib>Neuville, Luc</creatorcontrib><creatorcontrib>Moreau, Nicole J.</creatorcontrib><creatorcontrib>Genet, Jean-Pierre</creatorcontrib><creatorcontrib>dos Santos, Aldenir Feitosa</creatorcontrib><creatorcontrib>Caño de Andrade, Maria Cristina</creatorcontrib><creatorcontrib>Goulart Sant’Ana, Antônio Euzébio</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marquez, Béatrice</au><au>Neuville, Luc</au><au>Moreau, Nicole J.</au><au>Genet, Jean-Pierre</au><au>dos Santos, Aldenir Feitosa</au><au>Caño de Andrade, Maria Cristina</au><au>Goulart Sant’Ana, Antônio Euzébio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidrug resistance reversal agent from Jatropha elliptica</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>66</volume><issue>15</issue><spage>1804</spage><epage>1811</epage><pages>1804-1811</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Bioassay-guided fractionation of
Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of
Staphylococcus aureus.
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of
Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (
8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of
Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (
8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>16051285</pmid><doi>10.1016/j.phytochem.2005.06.008</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2005-08, Vol.66 (15), p.1804-1811 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00091888v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester Anti-Bacterial Agents - pharmacology antibacterial properties Antifungal Agents - pharmacology Biological and medical sciences Biological Factors Chemical constitution chemical structure Drug Resistance, Multiple - drug effects Efflux pump inhibitor Fluoroquinolone Fundamental and applied biological sciences. Psychology General pharmacology Jatropha Jatropha elliptica Kinetics Medical sciences medicinal plants Microbial Sensitivity Tests multiple drug resistance Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Extracts - pharmacology Plant physiology and development pyridines Resistance spectral analysis Staphylococcus aureus |
| title | Multidrug resistance reversal agent from Jatropha elliptica |
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