Kluyveromyces lactis repertoire of transcriptional regulators
We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction...
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| Veröffentlicht in: | FEMS yeast research 2006-05, Vol.6 (3), p.325-335 |
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| creator | Bussereau, Françoise Casaregola, Serge Lafay, Jean-François Bolotin-Fukuhara, Monique |
| description | We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data. |
| doi_str_mv | 10.1111/j.1567-1364.2006.00028.x |
| format | Article |
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Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data.</description><identifier>ISSN: 1567-1356</identifier><identifier>EISSN: 1567-1364</identifier><identifier>DOI: 10.1111/j.1567-1364.2006.00028.x</identifier><identifier>PMID: 16630273</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino Acid Motifs ; Biochemistry, Molecular Biology ; comparative genomics ; Computational Biology ; Deoxyribonucleic acid ; DNA ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA‐binding motifs ; Fungal Proteins - chemistry ; Fungal Proteins - genetics ; genes ; Genome, Fungal ; Genomes ; Genomics ; Kluyveromyces - genetics ; Kluyveromyces lactis ; Kluyveromyces marxianus var. lactis ; Life Sciences ; Molecular biology ; niches ; Nucleotide sequence ; nucleotide sequences ; Proteins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Trans-Activators - chemistry ; Trans-Activators - genetics ; transactivators ; Transcription ; Transcription, Genetic ; transcriptional regulation ; Yeast ; yeasts ; zinc</subject><ispartof>FEMS yeast research, 2006-05, Vol.6 (3), p.325-335</ispartof><rights>2005 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved 2005</rights><rights>2005 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4968-3ea53af0348ea534748ea4055e1ee7aeccd998ddd455e1f18a486cb7b22cea2f3</citedby><cites>FETCH-LOGICAL-c4968-3ea53af0348ea534748ea4055e1ee7aeccd998ddd455e1f18a486cb7b22cea2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1567-1364.2006.00028.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1567-1364.2006.00028.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16630273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00089673$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bussereau, Françoise</creatorcontrib><creatorcontrib>Casaregola, Serge</creatorcontrib><creatorcontrib>Lafay, Jean-François</creatorcontrib><creatorcontrib>Bolotin-Fukuhara, Monique</creatorcontrib><title>Kluyveromyces lactis repertoire of transcriptional regulators</title><title>FEMS yeast research</title><addtitle>FEMS Yeast Res</addtitle><description>We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data.</description><subject>Amino Acid Motifs</subject><subject>Biochemistry, Molecular Biology</subject><subject>comparative genomics</subject><subject>Computational Biology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA‐binding motifs</subject><subject>Fungal Proteins - chemistry</subject><subject>Fungal Proteins - genetics</subject><subject>genes</subject><subject>Genome, Fungal</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Kluyveromyces - genetics</subject><subject>Kluyveromyces lactis</subject><subject>Kluyveromyces marxianus var. lactis</subject><subject>Life Sciences</subject><subject>Molecular biology</subject><subject>niches</subject><subject>Nucleotide sequence</subject><subject>nucleotide sequences</subject><subject>Proteins</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Trans-Activators - chemistry</subject><subject>Trans-Activators - genetics</subject><subject>transactivators</subject><subject>Transcription</subject><subject>Transcription, Genetic</subject><subject>transcriptional regulation</subject><subject>Yeast</subject><subject>yeasts</subject><subject>zinc</subject><issn>1567-1356</issn><issn>1567-1364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkd9rFDEQx4Motlb_BV0QBB92ze9kQR9KsVY8ENQ--BRy2dmaI3dZk93a--_NuscJomBeZpj5fGcyMwhVBDekvFebhgipasIkbyjGssEYU93c3UOnx8T9oy_kCXqU8wZjojDWD9EJkZJhqtgpevMhTPtbSHG7d5CrYN3oc5VggDRGn6CKfTUmu8su-WH0cWdDyd5MwY4x5cfoQW9DhicHe4auL99-ubiqVx_fvb84X9WOt1LXDKxgtseM69njarYcCwEEQFlwrmtb3XUdn0M90ZZr6dZqTakDS3t2hl4udb_ZYIbktzbtTbTeXJ2vzBwr8-tWKnZLCvtiYYcUv0-QR7P12UEIdgdxykYqrWWrRQGf_wFu4pTKgNlQxgRlnKu2UHqhXIo5J-iP_Qk28zHMxsx7NvPOzXwM8-sY5q5Inx4aTOstdL-Fh-0X4PUC_PAB9v9d2Fx-_VScImeLPE7DP8T13371bFH1Nhp7k3w2158pJqLksdBMsJ_l1q-a</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Bussereau, Françoise</creator><creator>Casaregola, Serge</creator><creator>Lafay, Jean-François</creator><creator>Bolotin-Fukuhara, Monique</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><general>Oxford University Press (OUP)</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>200605</creationdate><title>Kluyveromyces lactis repertoire of transcriptional regulators</title><author>Bussereau, Françoise ; Casaregola, Serge ; Lafay, Jean-François ; Bolotin-Fukuhara, Monique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4968-3ea53af0348ea534748ea4055e1ee7aeccd998ddd455e1f18a486cb7b22cea2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amino Acid Motifs</topic><topic>Biochemistry, Molecular Biology</topic><topic>comparative genomics</topic><topic>Computational Biology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA‐binding motifs</topic><topic>Fungal Proteins - chemistry</topic><topic>Fungal Proteins - genetics</topic><topic>genes</topic><topic>Genome, Fungal</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Kluyveromyces - genetics</topic><topic>Kluyveromyces lactis</topic><topic>Kluyveromyces marxianus var. lactis</topic><topic>Life Sciences</topic><topic>Molecular biology</topic><topic>niches</topic><topic>Nucleotide sequence</topic><topic>nucleotide sequences</topic><topic>Proteins</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Trans-Activators - chemistry</topic><topic>Trans-Activators - genetics</topic><topic>transactivators</topic><topic>Transcription</topic><topic>Transcription, Genetic</topic><topic>transcriptional regulation</topic><topic>Yeast</topic><topic>yeasts</topic><topic>zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bussereau, Françoise</creatorcontrib><creatorcontrib>Casaregola, Serge</creatorcontrib><creatorcontrib>Lafay, Jean-François</creatorcontrib><creatorcontrib>Bolotin-Fukuhara, Monique</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>FEMS yeast research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bussereau, Françoise</au><au>Casaregola, Serge</au><au>Lafay, Jean-François</au><au>Bolotin-Fukuhara, Monique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kluyveromyces lactis repertoire of transcriptional regulators</atitle><jtitle>FEMS yeast research</jtitle><addtitle>FEMS Yeast Res</addtitle><date>2006-05</date><risdate>2006</risdate><volume>6</volume><issue>3</issue><spage>325</spage><epage>335</epage><pages>325-335</pages><issn>1567-1356</issn><eissn>1567-1364</eissn><abstract>We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16630273</pmid><doi>10.1111/j.1567-1364.2006.00028.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Amino Acid Motifs Biochemistry, Molecular Biology comparative genomics Computational Biology Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA‐binding motifs Fungal Proteins - chemistry Fungal Proteins - genetics genes Genome, Fungal Genomes Genomics Kluyveromyces - genetics Kluyveromyces lactis Kluyveromyces marxianus var. lactis Life Sciences Molecular biology niches Nucleotide sequence nucleotide sequences Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Trans-Activators - chemistry Trans-Activators - genetics transactivators Transcription Transcription, Genetic transcriptional regulation Yeast yeasts zinc |
| title | Kluyveromyces lactis repertoire of transcriptional regulators |
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