Combined Signaling through ERK, PI3K/AKT, and RAC1/p38 Is Required for Met-triggered Cortical Neuron Migration

Cell migration is a complex biological process playing a key role in physiological and pathological conditions. During central nervous system development, positioning and function of cortical neurons is tightly regulated by cell migration. Recently, signaling events involving the urokinase-type plas...

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Veröffentlicht in:	The Journal of biological chemistry 2006-02, Vol.281 (8), p.4771-4778
Hauptverfasser:	Segarra, Joseph, Balenci, Laurent, Drenth, Thijs, Maina, Flavio, Lamballe, Fabienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Movement Cellular Biology Extracellular Signal-Regulated MAP Kinases - metabolism Female Genotype Hepatocyte Growth Factor - metabolism Heterozygote JNK Mitogen-Activated Protein Kinases - metabolism Life Sciences Male Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Mutation Neurons - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - metabolism Plasmids - metabolism Proto-Oncogene Proteins c-met - physiology rac1 GTP-Binding Protein - metabolism Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction Time Factors
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