Total Synthesis and Determination of the Absolute Configuration of Coscinosulfate. A New Selective Inhibitor of Cdc25 Protein Phosphatase

The first total synthesis of coscinosulfate 1, a metabolite isolated from a sea sponge, starting from (+)-sclareolide 3 is described. The convergent synthesis strategy relies on the coupling of sulfone 21 with the bromide 26. The sulfone fragment 21 was obtained by successive asymmetric aldol reacti...

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Veröffentlicht in:	Journal of organic chemistry 2001-11, Vol.66 (22), p.7263-7269
Hauptverfasser:	Poigny, Stéphane, Nouri, Samia, Chiaroni, Angèle, Guyot, Michèle, Samadi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemistry Biochemistry Biochemistry, Molecular Biology cdc25 Phosphatases - antagonists & inhibitors Diterpenes - chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Life Sciences Molecular Conformation Porifera - chemistry Sesterterpenes Stereoisomerism Terpenes - chemical synthesis Terpenes - chemistry
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