Two cyclopeptides from the seeds of Annona cherimola

The structures of cherimolacyclopeptides E and F were elucidated on the basis of their MS/MS spectra, chemical degradation and extensive 2D NMR experiments. Bioassay-guided fractionation of cytotoxic of methanol extract of the seeds of Annona cherimola provided two novel cyclic peptides, cherimolacy...

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Veröffentlicht in:	Phytochemistry (Oxford) 2005-10, Vol.66 (19), p.2376-2380
Hauptverfasser:	Wélé, Alassane, Zhang, Yanjun, Brouard, Jean-Paul, Pousset, Jean-Louis, Bodo, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Annona Annona - chemistry Annona cherimola Annonaceae Antineoplastic Agents, Phytogenic Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biochemistry Biochemistry, Molecular Biology Biological and medical sciences Cell Survival Cell Survival - drug effects Chemical constitution Chemical Sciences Cherimolacyclopeptide E Cherimolacyclopeptide F Cyclopeptide Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Glycoproteins Humans Inhibitory Concentration 50 KB Cells Life Sciences Magnetic Resonance Spectroscopy Molecular Sequence Data Organic chemistry Peptides, Cyclic Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Plant physiology and development Proteins Seeds Seeds - chemistry Spectrometry, Mass, Electrospray Ionization
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