Programmed cell death in parasitic protozoans that lack mitochondria
In multicellular organisms and in all protozoans harbouring mitochondria, the pathways leading to programmed cell death (PCD) are localized in the mitochondria. Intriguingly, unicellular parasites devoid of mitochondria such as Trichomonas vaginalis and Giardia intestinalis undergo a form of cell de...
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| Veröffentlicht in: | Trends in parasitology 2003-12, Vol.19 (12), p.559-564 |
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| creator | Chose, Olivier Sarde, Claude-Olivier Gerbod, Delphine Viscogliosi, Eric Roseto, Alberto |
| description | In multicellular organisms and in all protozoans harbouring mitochondria, the pathways leading to programmed cell death (PCD) are localized in the mitochondria. Intriguingly, unicellular parasites devoid of mitochondria such as
Trichomonas vaginalis and
Giardia intestinalis undergo a form of cell death resembling apoptosis, the most frequent form of PCD. This reinforces the idea that PCD must have evolved before the evolution of multicellularity. Moreover, this leads to the hypothesis of an early emergence of death pathways in eukaryotes preceding mitochondrial endosymbiosis and brings into question the central role of mitochondria in PCD. |
| doi_str_mv | 10.1016/j.pt.2003.09.016 |
| format | Article |
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Trichomonas vaginalis and
Giardia intestinalis undergo a form of cell death resembling apoptosis, the most frequent form of PCD. This reinforces the idea that PCD must have evolved before the evolution of multicellularity. Moreover, this leads to the hypothesis of an early emergence of death pathways in eukaryotes preceding mitochondrial endosymbiosis and brings into question the central role of mitochondria in PCD.</description><identifier>ISSN: 1471-4922</identifier><identifier>EISSN: 1471-5007</identifier><identifier>DOI: 10.1016/j.pt.2003.09.016</identifier><identifier>PMID: 14642765</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Apoptosis - physiology ; Biological and medical sciences ; Biological Evolution ; Eukaryota - physiology ; Fundamental and applied biological sciences. Psychology ; Giardia intestinalis ; Life cycle. Host-agent relationship. Pathogenesis ; Life Sciences ; Mitochondria - physiology ; Necrosis ; Protozoa ; Symbiosis - physiology ; Trichomonas vaginalis ; Trichomonas vaginalis - physiology</subject><ispartof>Trends in parasitology, 2003-12, Vol.19 (12), p.559-564</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-86ee23d4754ee119e8d42c55f9fcbf77f0c5747c6a3214547c0043a078ab25103</citedby><cites>FETCH-LOGICAL-c441t-86ee23d4754ee119e8d42c55f9fcbf77f0c5747c6a3214547c0043a078ab25103</cites><orcidid>0000-0002-5805-7179</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pt.2003.09.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15308131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14642765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00086072$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chose, Olivier</creatorcontrib><creatorcontrib>Sarde, Claude-Olivier</creatorcontrib><creatorcontrib>Gerbod, Delphine</creatorcontrib><creatorcontrib>Viscogliosi, Eric</creatorcontrib><creatorcontrib>Roseto, Alberto</creatorcontrib><title>Programmed cell death in parasitic protozoans that lack mitochondria</title><title>Trends in parasitology</title><addtitle>Trends Parasitol</addtitle><description>In multicellular organisms and in all protozoans harbouring mitochondria, the pathways leading to programmed cell death (PCD) are localized in the mitochondria. Intriguingly, unicellular parasites devoid of mitochondria such as
Trichomonas vaginalis and
Giardia intestinalis undergo a form of cell death resembling apoptosis, the most frequent form of PCD. This reinforces the idea that PCD must have evolved before the evolution of multicellularity. Moreover, this leads to the hypothesis of an early emergence of death pathways in eukaryotes preceding mitochondrial endosymbiosis and brings into question the central role of mitochondria in PCD.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Eukaryota - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Giardia intestinalis</subject><subject>Life cycle. Host-agent relationship. 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Psychology</topic><topic>Giardia intestinalis</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Life Sciences</topic><topic>Mitochondria - physiology</topic><topic>Necrosis</topic><topic>Protozoa</topic><topic>Symbiosis - physiology</topic><topic>Trichomonas vaginalis</topic><topic>Trichomonas vaginalis - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chose, Olivier</creatorcontrib><creatorcontrib>Sarde, Claude-Olivier</creatorcontrib><creatorcontrib>Gerbod, Delphine</creatorcontrib><creatorcontrib>Viscogliosi, Eric</creatorcontrib><creatorcontrib>Roseto, Alberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Trends in parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chose, Olivier</au><au>Sarde, Claude-Olivier</au><au>Gerbod, Delphine</au><au>Viscogliosi, Eric</au><au>Roseto, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Programmed cell death in parasitic protozoans that lack mitochondria</atitle><jtitle>Trends in parasitology</jtitle><addtitle>Trends Parasitol</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>19</volume><issue>12</issue><spage>559</spage><epage>564</epage><pages>559-564</pages><issn>1471-4922</issn><eissn>1471-5007</eissn><abstract>In multicellular organisms and in all protozoans harbouring mitochondria, the pathways leading to programmed cell death (PCD) are localized in the mitochondria. 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| ispartof | Trends in parasitology, 2003-12, Vol.19 (12), p.559-564 |
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| subjects | Animals Apoptosis - physiology Biological and medical sciences Biological Evolution Eukaryota - physiology Fundamental and applied biological sciences. Psychology Giardia intestinalis Life cycle. Host-agent relationship. Pathogenesis Life Sciences Mitochondria - physiology Necrosis Protozoa Symbiosis - physiology Trichomonas vaginalis Trichomonas vaginalis - physiology |
| title | Programmed cell death in parasitic protozoans that lack mitochondria |
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