Mechanisms for picrotoxin block of alpha2 homomeric glycine receptors

It is well known that the convulsant alkaloid picrotoxin (PTX) can inhibit neuronal gamma-aminobutyric acid (GABA) and homomeric glycine receptors (GlyR). However, the mechanism for PTX block of alpha(2) homomeric GlyR is still unclear compared with that of alpha(1) homomeric GlyR, GABA(A), and GABA...

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Veröffentlicht in:	The Journal of biological chemistry 2005, Vol.281, p.3841-3855
Hauptverfasser:	Wang, D.S., Mangin, J.M., Moonen, G., Rigo, J.M., Legendre, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cognitive Sciences Life Sciences Neurons and Cognition
Online-Zugang:	Volltext
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