The chemosensitivity to therapy of childhood early B acute lymphoblastic leukemia could be determined by the combined expression of CD34, SPI-B and BCR genes

We have identified genes differentially expressed in childhood early B acute lymphoblastic leukemia at diagnosis, according to chemosensitivity. Chemosensitive (M1) and chemoresistant (M3) patients present 25% of residual leukemic blasts at 21 days of treatment, respectively. The expression profiles...

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Veröffentlicht in:	Leukemia research 2006-06, Vol.30 (6), p.665-676
Hauptverfasser:	Talby, Leila, Chambost, Hervé, Roubaud, Marie-Christine, N’Guyen, Catherine, Milili, Michèle, Loriod, Béatrice, Fossat, Chantal, Picard, Christophe, Gabert, Jean, Chiappetta, Pierre, Michel, Gérard, Schiff, Claudine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Anthracyclines - administration & dosage Antigens, CD34 - biosynthesis Antigens, CD34 - genetics Antineoplastic Combined Chemotherapy Protocols - administration & dosage Asparaginase - administration & dosage Blast Crisis - drug therapy Blast Crisis - genetics Blast Crisis - metabolism Blast Crisis - pathology Burkitt Lymphoma - drug therapy Burkitt Lymphoma - genetics Burkitt Lymphoma - metabolism Burkitt Lymphoma - pathology Chemosensitivity to therapy Child Child, Preschool Cortisone - administration & dosage DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Drug Resistance, Neoplasm - genetics Female Gene expression profiles Gene Expression Profiling - methods Gene Expression Regulation, Leukemic - genetics Humans Immunology Infant Life Sciences Male Microarray Oligonucleotide Array Sequence Analysis - methods Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Predictive Value of Tests Proto-Oncogene Proteins c-bcr - biosynthesis Proto-Oncogene Proteins c-bcr - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Vincristine - administration & dosage
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