p53 Inactivation leads to impaired motor synchronization in mice

We have combined genetic and pharmacological approaches to investigate the behavioural consequences of inactivation of the murine p53 protein. Our behavioural analysis revealed that p53‐null mice (p53KO) exhibit a very specific and significant motor deficit in rapid walking synchronization. This def...

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Veröffentlicht in:	The European journal of neuroscience 2003-05, Vol.17 (10), p.2135-2146
Hauptverfasser:	Campana, Aline L. M., Rondi-Reig, Laure, Tobin, Christine, Lohof, Ann M., Picquet, Florence, Falempin, Maurice, Weitzman, Jonathan B., Mariani, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzothiazoles cerebellum Cerebellum - pathology Cerebellum - physiopathology Cognitive Sciences Lameness, Animal - pathology Lameness, Animal - physiopathology Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity motor behaviour Motor Neurons - pathology Motor Neurons - physiology Muscle Fibers, Fast-Twitch - pathology Muscle, Skeletal - innervation Muscle, Skeletal - pathology Neuromuscular Junction - pathology Neurons and Cognition Olivary Nucleus - pathology Olivary Nucleus - physiopathology Organ Culture Techniques p53 p53KO pifithrin Thiazoles - pharmacology Toluene - analogs & derivatives Toluene - pharmacology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Walking
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