Behavioral and neurochemical effects induced by subchronic combined exposure to toluene at 40 ppm and noise at 80 dB-A in rats

We investigated whether exposure to noise, in addition to its well-known potentiating effect on toluene-induced ototoxicity, may also exacerbate behavioral disturbances and brain neurochemical alterations produced by subchronic exposure to low toluene concentration. To test this hypothesis, we evalu...

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Veröffentlicht in:	Physiology & behavior 2004-05, Vol.81 (3), p.527-534
Hauptverfasser:	Berenguer, Patrick, Soulage, Christophe, Fautrel, Alain, Péquignot, Jean-Marc, Abraini, Jacques H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal ethology Animals Behavior, Animal - drug effects Behavior, Animal - physiology Behavioral Biological and medical sciences Body Weight - drug effects Body Weight - physiology Brain Chemistry - drug effects Caudate Nucleus - drug effects Caudate Nucleus - metabolism Combined exposure CYP2E1 Cytochrome P-450 CYP2E1 - metabolism Dopamine - biosynthesis Female Female rats Fundamental and applied biological sciences. Psychology Life Sciences Liver Male Mammalia Microsomes, Liver - drug effects Microsomes, Liver - enzymology Microsomes, Liver - physiology Motor Activity - drug effects Motor Activity - physiology Neurochemical Noise Noise - adverse effects Other Psychology. Psychoanalysis. Psychiatry Putamen - drug effects Putamen - metabolism Rats Rats, Sprague-Dawley Serotonin - biosynthesis Solvents Subchronic Toluene Toluene - toxicity Tryptophan Hydroxylase - metabolism Tyrosine 3-Monooxygenase - metabolism Vertebrata
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