Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia

Fanconi's syndrome (FS) is a disorder of sodium-dependent proximal tubule reabsorption, which may complicate plasma cell disorders producing a free monoclonal light chain (LC). FS often occurs in the setting of smoldering myeloma and features cytoplasmic crystalline inclusions of monoclonal kap...

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Veröffentlicht in:	American journal of kidney diseases 2005-04, Vol.45 (4), p.749-757
Hauptverfasser:	Bridoux, Frank, Sirac, Christophe, Hugue, Valérie, Decourt, Catherine, Thierry, Antoine, Quellard, Nathalie, Abou-Ayache, Ramzi, Goujon, Jean-Michel, Cogné, Michel, Touchard, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino Acid Sequence Antibodies, Monoclonal Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - urine Base Sequence Biopsy Bone Marrow Bone Marrow - pathology Fanconi Syndrome Fanconi Syndrome - etiology Fanconi Syndrome - immunology Fanconi Syndrome - pathology Genes, Immunoglobulin Germ-Line Mutation Humans Immunoglobulin kappa-Chains Immunoglobulin kappa-Chains - genetics Immunoglobulin kappa-Chains - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin Variable Region Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Immunology Kidney Kidney - pathology Kidney Failure, Chronic Kidney Failure, Chronic - etiology Kidney Tubules, Proximal Kidney Tubules, Proximal - immunology Kidney Tubules, Proximal - pathology Life Sciences Male Molecular Sequence Data Protein Structure, Tertiary Sequence Alignment Sequence Analysis, DNA Sequence Homology, Nucleic Acid Trypsin Trypsin - metabolism Waldenstrom Macroglobulinemia Waldenstrom Macroglobulinemia - complications Waldenstrom Macroglobulinemia - genetics Waldenstrom Macroglobulinemia - immunology
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